Human IL1RN

The product is shipped at ambient temperature.

Recombinant Human Interleukin-1 Receptor Antagonist Protein/IL-1RN is produced with our E. coli expression system. The target protein is expressed with sequence (Arg26-Glu177) of Human IL1RN.

Interleukin-1 Receptor Antagonist (IL-1RN) is a member of the IL-1 family. Endogenous IL-1RN is produced in numerous animal disease models as well as in human autoimmune & chronic inflammatory diseases. It binds to IL-1 receptors in competition with IL-1, but does not elicit intracellular response from this binding. Its role in counteracting the proinflammatory effects of IL-1 is being studied by numerous research groups. IL-4 & IL-13 have been shown to amplify the stimulatory effect of IL1-beta on the production of soluble & intracellular forms of IL-1RN. The regulated expression of IL-1RN in various cell types has been shown to be influenced by cytokines. In synovial fibroblasts, IL-1, TNF-alpha, or PDGF markedly enhances the synthesis of IL-1RN.

Always centrifuge tubes before opening. Do not mix by vortex or pipetting.
It is not recommended to reconstitute to a concentration less than 100 ug/ml.
Dissolve the lyophilized protein in 2X PBS.
Please aliquot the reconstituted solution.