NAIP Recombinant Protein

Protein

Root Catalog/Products/Recombinant Proteins

29kDa

NLR family apoptosis inhibitory protein

Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.

Anti-apoptotic protein which acts by inhibiting the activities of CASP3, CASP7 and CASP9. Can inhibit the autocleavage of pro-CASP9 and cleavage of pro-CASP3 by CASP9. Capable of inhibiting CASP9 autoproteolysis at 'Asp-315' and decreasing the rate of auto proteolysis at 'Asp-330'. Acts as a mediator of neuronal survival in pathological conditions. Prevents motor-neuron apoptosis induced by a variety of signals. Possible role in the prevention of spinal muscular atrophy that seems to be caused by inappropriate persistence of motor-neuron apoptosis: mutated or deleted forms of NAIP have been found in individuals with severe spinal muscular atrophy.

NP_004527.2

650 ug/mL (prior to lyoph)