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VHL Recombinant Protein

VHL Recombinant Protein

Item no.	OPCD07915
Manufacturer	AVIVA Systems Biology
Amount	10 ug
Category	Oncology Metabolism Diabetes Glucose Homeostasis By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Obesity Immunoprecipitation Western Blot ELISA SDS-PAGE Cardiovascular Research Heart Failure Myocardial Infarction Hypertension Arrhythmias
Type	Proteins Recombinant
Applications	WB, SDS-PAGE
Specific against	Rat (Rattus norvegicus)
Host	E.coli
Conjugate/Tag	Unconjugated; HIS
Purity	>95%
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	pVHL;Vhlh;von Hippel-Lindau disease tumor suppressor;von Hippel-Lindau protein;von Hippel-Lindau syndrome homolog;von Hippel-Lindau tumor suppressor,E3 ubiquitin protein ligase.
Available
Manufacturer - Type	Protein
Manufacturer - Applications	Positive control\|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis\|Western blot
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Manufacturer - Conjugate / Tag	N-terminal His Tag
Molecular Weight	23kDa
Gene symbol	Vhl
Gene Fullname	von Hippel-Lindau tumor suppressor
Protein size	Recombinant
Product format	Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
Reconstitution and storage	2°C to 8°C\|-80°C
Description of target	Involved in the ubiquitination and subsequent proteasomal degradation via the von Hippel-Lindau ubiquitination complex. Seems to act as a target recruitment subunit in the E3 ubiquitin ligase complex and recruits hydroxylated hypoxia-inducible factor (HIF) under normoxic conditions. Involved in transcriptional repression through interaction with HIF1A, HIF1AN and histone deacetylases. Ubiquitinates, in an oxygen-responsive manner, ADRB2 (By similarity).
Nucleotide accession_num	NM_052801.1
Protein accession_num	NP_434688.1
Protein name	von Hippel-Lindau disease tumor suppressor
Formulation	PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
Concentration	200 ug/mL (prior to lyoph)

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 11/13/2025

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