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ADIPOQ Recombinant Protein (Human)

ADIPOQ Recombinant Protein (Human)

Item no.	OPED00006
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins Recombinant
Format	Lyophilized
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Purity	>90% (SDS-PAGE)
Citations	Activation of the LH receptor up regulates the type 2 adiponectin receptor in human granulosa cells: E.P. 3rd Wickham, et al.; J. Assist. Reprod. Genet. 30, 963 (2013), Abstract; Full Text Adiponectin and its receptors in the ovary: further evidence for a link between obesity and hyperandrogenism in polycystic ovary syndrome: F.V. Comim, et al.; PLoS One 8, e80416 (2013), Abstract; Full Text Adiponectin inhibits neutrophil phagocytosis of Escherichia coli by inhibition of PKB and ERK 1/2 MAPK signalling and Mac-1 activation: A. Rossi, et al.; PLoS One 8, e69108 (2013), Abstract; Full Text Adiponectin induces CCL20 expression synergistically with IL-6 and TNF-alpha in THP-1 macrophages: M. Suzuki, et al.; Cytokine 58, 344 (2012), Abstract; Inhibition of smooth muscle cell proliferation by adiponectin requires proteolytic conversion to its globular form: M. Fuerst, et al.; J. Endocrinol. 215, 107 (2012), Abstract; Full Text Globular adiponectin counteracts VCAM-1-mediated monocyte adhesion via AdipoR1/NF-kappa B/COX-2 signaling in human aortic endothelial cells: F. Addabbo, et al.; Am. J. Physiol. Endocrinol. Metab. 301, E1143 (2011), Application(s): WB of human aortic endothelial cells, Abstract; Full Text Adipose tissue explants and MDCK cells reciprocally regulate their morphogenesis in coculture: K. Udo, et al.; Kidney Int. 78, 60 (2010), Abstract; Sialic acid modification of adiponectin is not required for multimerization or secretion but determines half-life in circulation: A.A. Richards, et al.; Mol. Endocrinol. 24, 229 (2010), Abstract; Leptin stimulates fatty acid oxidation and peroxisome proliferator-activated receptor alpha gene expression in mouse C2C12 myoblasts by changing the subcellular localization of the alpha 2 form of AMP-activated protein kinase: A. Suzuki, et al.; Mol. Cell. Biol. 27, 4317 (2007), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	30 kDa adipocyte complement-related protein;ACDC;ACRP30;adipocyte complement-related 30 kDa protein;Adipocyte,C1q and collagen domain-containing protein;adiponectin;adipose most abundant gene transcript 1 protein;adipose specific collagen-like factor;ADIPQTL1;ADPN;APM1;APM-1;GBP28;Gelatin-binding protein;gelatin-binding protein 28.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	33 kDa
Gene symbol	ADIPOQ
Gene Fullname	adiponectin, C1Q and collagen domain containing
Protein size	Recombinant
Product format	Lyophilized. Contains PBS.
Reconstitution and storage	Reconstitute with 50 ul sterile distilled water. Further dilutions should be made with medium containing 5% fetal calf serum or other carrier protein. Store at -20C
Description of target	Important adipokine involved in the control of fat metabolism and insulin sensitivity, with direct anti-diabetic, anti-atherogenic and anti-inflammatory activities. Stimulates AMPK phosphorylation and activation in the liver and the skeletal muscle, enhancing glucose utilization and fatty-acid combustion. Antagonizes TNF-alpha by negatively regulating its expression in various tissues such as liver and macrophages, and also by counteracting its effects. Inhibits endothelial NF-kappa-B signaling through a cAMP-dependent pathway. May play a role in cell growth, angiogenesis and tissue remodeling by binding and sequestering various growth factors with distinct binding affinities, depending on the type of complex, LMW, MMW or HMW.
Nucleotide accession_num	NM_001223.4
Protein accession_num	NP_001214.1
Protein name	Adiponectin

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 11/13/2025

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