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BACE2 Recombinant Protein (Human)

BACE2 Recombinant Protein (Human)

Item no.	OPED00008
Manufacturer	AVIVA Systems Biology
Amount	10 ug
Category	Oncology Neuroscience Molecular Targets for Neuroscience Aging & Neurological Disorders Protein Aggregation, Clearance & Misfolding By Cell Type Peptides & Proteins Recombinant Proteins Adenocarcinoma
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Insect Cells
Purity	>80% (SDS-PAGE)
Dry ice	Yes
Citations	BACE1 and BACE2 enzymatic activities in Alzheimerâ€™s disease: R.R. Ahmed, et al.; J. Neurochem. 112, 1045 (2009), Abstract; Characterization of a mouse model overexpressing beta -site APP-cleaving enzyme 2 reveals a new role for BACE2: G. Azkona, et al.; Genes Brain Behav. 9, 160 (2009), Abstract; BACE2 is stored in secretory granules of mouse and rat pancreatic beta cells: G. Finzi, et al.; Ultrastruct. Pathol. 32, 246 (2008), Abstract; Altered beta -secretase enzyme kinetics and levels of both BACE1 and BACE2 in the Alzheimerâ€™s disease brain: J.H. Stockley, et al.; FEBS Lett. 580, 6550 (2006), Abstract; BACE1 and BACE2 in pathologic and normal human muscle: G. Vattemi, et al.; Exp. Neurol. 179, 150 (2003), Abstract; Specificity of memapsin 1 and its implications on the design of memapsin 2 (beta -secretase) inhibitor selectivity: R.T. Turner 3rd, et al.; Biochemistry 41, 8742 (2002), Abstract; Substrate and inhibitor profile of BACE (beta -secretase) and comparison with other mammalian aspartic proteases: F. Gruninger-Leitch, et al.; J. Biol. Chem. 277, 4687 (2002), Abstract; ASP1 (BACE2) cleaves the amyloid precursor protein at the beta -secretase site: I. Hussain, et al.; Mol. Cell. Neurosci. 16, 609 (2000), Abstract; Human aspartic protease memapsin 2 cleaves the beta -secretase site of beta -amyloid precursor protein: X. Lin, et al.; PNAS 97, 1456 (2000), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	56 kDa aspartic-like protease;AEPLC;ALP56;ASP1;ASP21;Aspartic-like protease 56 kDa;aspartyl protease 1;BAE2;beta-secretase 2;beta-site amyloid beta A4 precursor protein-cleaving enzyme 2;Beta-site amyloid precursor protein cleaving enzyme 2;beta-site APP-cleaving enzyme 2;CDA13;CEAP1;Down region aspartic protease;Down syndrome region aspartic protease;DRAP;memapsin-1;membrane-associated aspartic protease 1;SLCO3A1/BACE2 fusion;theta-secretase;transmembrane aspartic proteinase Asp1.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	48 kDa doublet
Manufacturer - Application Additional Information	Useful tool to study enzyme kinetics, cleave target substrates, and screen for BACE2 inhibitors or BACE1 inhibitor selectivity.
Gene symbol	BACE2
Gene Fullname	beta-secretase 2
Protein size	Recombinant
Product format	Liquid. In 50mM TRIS-HCl, pH 7.5, containing 100mM sodium chloride and 20% glycerol.
Reconstitution and storage	Store at -80C
Description of target	Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672.
Nucleotide accession_num	NM_001225.3
Protein accession_num	NP_001216.1
Protein name	Beta-secretase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 12/25/2025

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