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PTPN1 Recombinant Protein (Human)

PTPN1 Recombinant Protein (Human)

Item no.	OPED00122
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neural Lineage Markers By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Myelofibrosis Mesothelioma Stem Cell Markers
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>95% (SDS-PAGE)
Dry ice	Yes
Citations	High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida: Y. Tahtah, et al.; Fitoterapia 110, 52 (2016), Application(s): PTP1B enzyme was used for the microplate-based PTP1B inhibition assay, Abstract; The potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron: A. Saifudin, et al.; Pharmacognosy Res. 8, 38 (2016), Application(s): Protein tyrosine phosphatase 1B inhibitory activity, Full Text Antihyperglycemic and antioxidant activities of twig extract from Cinnamomum osmophloeum: G.M. Lin, et al.; J. Tradit. Complement. Med. (2015), Application(s): Assay, Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies: J.S. Choi, et al.; J. Ethnopharmacol. 171, 28 (2015), Application(s): Inhibition Assay, Abstract; Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects: P. H. Nguyen, et al.; Bioorg. Med. Chem. 23, 3730 (2015), Application(s): Assay, Abstract; Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from the marine-derived fungus Trichoderma sp: H. Yamazaki, et al.; J. Antibiot. (Tokyo) 68, 628 (2015), Application(s): Inhibitory Assay, Abstract; Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity: N. Li, et al.; Phytochem. Lett. 13, 286 (2015), Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae): S.H. Tiong, et al.; Fitoterapia 102, 182 (2015), Application(s): Assay, Abstract; Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract; Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design: Y.A. Puius, et al.; PNAS 94, 13420 (1997), Abstract; Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas): F. Liu, et al.; J. Biol. Chem. 271, 31290 (1996), Abstract;High-resolution PTP1B inhibition profiling combined with high-performance liquid chromatography-high-resolution mass spectrometry-solid-phase extraction-nuclear magnetic resonance spectroscopy: Proof-of-concept and antidiabetic constituents in crude extract of Eremophila lucida: Y. Tahtah, et al.; Fitoterapia 110, 52 (2016), Application(s): PTP1B enzyme was used for the microplate-based PTP1B inhibition assay, Abstract; The potent inhibitors of protein tyrosine phosphatase 1B from the fruits of Melaleuca leucadendron: A. Saifudin, et al.; Pharmacognosy Res. 8, 38 (2016), Application(s): Protein tyrosine phosphatase 1B inhibitory activity, Full Text Antihyperglycemic and antioxidant activities of twig extract from Cinnamomum osmophloeum: G.M. Lin, et al.; J. Tradit. Complement. Med. (2015), Application(s): Assay, Protein tyrosine phosphatase 1B inhibitory activity of alkaloids from Rhizoma Coptidis and their molecular docking studies: J.S. Choi, et al.; J. Ethnopharmacol. 171, 28 (2015), Application(s): Inhibition Assay, Abstract; Selaginellin and biflavonoids as protein tyrosine phosphatase 1B inhibitors from Selaginella tamariscina and their glucose uptake stimulatory effects: P. H. Nguyen, et al.; Bioorg. Med. Chem. 23, 3730 (2015), Application(s): Assay, Abstract; Trichoketides A and B, two new protein tyrosine phosphatase 1B inhibitors from the marine-derived fungus Trichoderma sp: H. Yamazaki, et al.; J. Antibiot. (Tokyo) 68, 628 (2015), Application(s): Inhibitory Assay, Abstract; Two new diphenyl ethers from Acanthopanax senticosus (Rupr. & Maxim.) Harms with PTP1B inhibitory activity: N. Li, et al.; Phytochem. Lett. 13, 286 (2015), Vindogentianine, a hypoglycemic alkaloid from Catharanthus roseus (L.) G. Don (Apocynaceae): S.H. Tiong, et al.; Fitoterapia 102, 182 (2015), Application(s): Assay, Abstract; Development of a highly potent, selective, and cell-active Inhibitor of cysteine cathepsin L-A hybrid design approach: D. Dana, et al.; Chem. Commun. (Camb.) 50, 10875 (2014), Abstract; Identification of a second aryl phosphate-binding site in protein-tyrosine phosphatase 1B: a paradigm for inhibitor design: Y.A. Puius, et al.; PNAS 94, 13420 (1997), Abstract; Direct binding of the proline-rich region of protein tyrosine phosphatase 1B to the Src homology 3 domain of p130(Cas): F. Liu, et al.; J. Biol. Chem. 271, 31290 (1996), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	protein tyrosine phosphatase,placental;protein-tyrosine phosphatase 1B;PTP1B;tyrosine-protein phosphatase non-receptor type 1.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	37 kDa
Manufacturer - Application Additional Information	Useful for the study of tyrosine phosphatase kinetics, substrate specificity and for screening inhibitors.
Gene symbol	PTPN1
Gene Fullname	protein tyrosine phosphatase non-receptor type 1
Protein size	Recombinant
Product format	Liquid. In 50mM HEPES, pH7.2, containing 1mM EDTA, 5mM DTT, and 0.05% NP-40.
Reconstitution and storage	Store at -80C
Description of target	Tyrosine-protein phosphatase which acts as a regulator of endoplasmic reticulum unfolded protein response. Mediates dephosphorylation of EIF2AK3/PERK; inactivating the protein kinase activity of EIF2AK3/PERK. May play an important role in CKII- and p60c-src-induced signal transduction cascades. May regulate the EFNA5-EPHA3 signaling pathway which modulates cell reorganization and cell-cell repulsion. May also regulate the hepatocyte growth factor receptor signaling pathway through dephosphorylation of MET.
Nucleotide accession_num	NM_001283041.1
Protein accession_num	NP_001269970.1
Protein name	Tyrosine-protein phosphatase non-receptor type 1
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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