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PTPN11 Recombinant Protein (Human)

PTPN11 Recombinant Protein (Human)

Item no.	OPED00130
Manufacturer	AVIVA Systems Biology
Amount	20 ug
Category	Oncology Neuroscience Neural Signaling By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Cell Biology Adenocarcinoma Cytoskeleton Astrocytoma By Organ Bladder Cancer small GTPases Rho Subfamily
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>90% (SDS-PAGE)
Dry ice	Yes
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	BPTP3;CFC;JMML;METCDS;NS1;protein-tyrosine phosphatase 1D;protein-tyrosine phosphatase 2C;PTP-1D;PTP2C;SH2 domain-containing protein tyrosine phosphatase 2;SHP2;SH-PTP2;SH-PTP3;tyrosine-protein phosphatase non-receptor type 11.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	68 kDa
Gene symbol	PTPN11
Gene Fullname	protein tyrosine phosphatase non-receptor type 11
Protein size	Recombinant
Product format	Liquid. In 10mM MES, pH 5.7, containing 100mM NaCl, 5mM DTT and 33% glycerol.
Reconstitution and storage	Store at -80C
Description of target	Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway (PubMed:28074573). Dephosphorylates GAB1, ARHGAP35 and EGFR (PubMed:28074573). Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73 (PubMed:26742426).
Nucleotide accession_num	NM_001171940.1
Protein accession_num	NP_001165411.2
Protein name	Tyrosine-protein phosphatase non-receptor type 11
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 20 ug

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Delivery expected until 12/25/2025

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