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TNF Recombinant Protein (Human)

TNF Recombinant Protein (Human)

Item no.	OPED00138
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Neuroscience Neuroinflammation Metabolism Diabetes Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Status Necrosis Apoptosis ELISA Immunostaining
Type	Proteins Recombinant
Format	Lyophilized
Applications	ELISA
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>95% (SDS-PAGE)
Citations	Cellular IAP proteins and LUBAC differentially regulate necrosome-associated RIP1 ubiquitination: M.C. de Almagro, et al.; Cell Death Dis. 6, e1800 (2015), Application(s): Cell Culture, Abstract; Full Text Small-molecule modulators of the OX40-OX40L costimulatory protein-protein interaction: Y. Song, et al.; Br. J. Pharmacol. 171, 4955 (2014), Abstract; De-ubiquitinating proteases USP2a and USP2c cause apoptosis by stabilising RIP1: A.L. Mahul-Mellier, et al.; Biochim. Biophys. Acta 1823, 1353 (2012), Abstract; NF-kappa B regulates thrombin-induced ICAM-1 gene expression in cooperation with NFAT by binding to the intronic NF-kappa B site in the ICAM-1 gene: J. Xue, et al.; Physiol. Genomics 38, 42 (2009), Abstract; Full Text The chemokine receptor CCR7 activates in dendritic cells two signaling modules that independently regulate chemotaxis and migratory speed: L. Riol-Blanco, et al.; J. Immunol. 174, 4070 (2005), Abstract; Full Text BAFF production by antigen-presenting cells provides T cell co-stimulation: B. Huard, et al.; Int. Immunol. 16, 467 (2004), Abstract; A second step of chemotaxis after transendothelial migration: keratinocytes undergoing apoptosis release IFN-gamma-inducible protein 10, monokine induced by IFN-gamma, and IFN-gamma-inducible alpha -chemoattractant for T cell chemotaxis toward epidermis in: S. Klunker, et al.; J. Immunol. 171, 1078 (2003), Abstract; Full Text Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes: O. Micheau & J. Tschopp; Cell 114, 181 (2003), Abstract; Insulin-secreting beta -cell dysfunction induced by human lipoproteins: M.E. Roehrich, et al.; J. Biol. Chem. 278, 18368 (2003), Abstract; Full Text Conversion of membrane-bound Fas(CD95) ligand to its soluble form is associated with downregulation of its proapoptotic activity and loss of liver toxicity: P. Schneider, et al.; J. Exp. Med. 187, 1205 (1998), Abstract; Full Text
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	APC1 protein;Cachectin;DIF;TNF,macrophage-derived;TNF,monocyte-derived;TNF-a;TNFA;TNF-alpha;TNFSF2;TNLG1F;tumor necrosis factor;tumor necrosis factor ligand 1F;tumor necrosis factor ligand superfamily member 2;tumor necrosis factor-alpha.
Shipping Condition	Cool pack
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Wet Ice
Molecular Weight	19 kDa
Manufacturer - Application Additional Information	ELISA: binds to TNF-R2 at 0.1-10 ng.
Gene symbol	TNF
Gene Fullname	tumor necrosis factor
Protein size	Recombinant
Product format	Lyophilized. Contains PBS.
Reconstitution and storage	Reconstitute with 50 ul sterile water. Further dilutions should be made with medium containing 5% fetal calf serum. Store at -20C
Description of target	Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation. Impairs regulatory T-cells (Treg) function in individuals with rheumatoid arthritis via FOXP3 dephosphorylation. Upregulates the expression of protein phosphatase 1 (PP1), which dephosphorylates the key 'Ser-418' residue of FOXP3, thereby inactivating FOXP3 and rendering Treg cells functionally defective (PubMed:23396208). Key mediator of cell death in the anticancer action of BCG-stimulated neutrophils in combination with DIABLO/SMAC mimetic in the RT4v6 bladder cancer cell line (PubMed:22517918).
Nucleotide accession_num	NC_000913.3
Protein accession_num	NP_418300.1
Protein name	Tumor necrosis factor

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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