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UBA1 Recombinant Protein (Human)

UBA1 Recombinant Protein (Human)

Item no.	OPED00157
Manufacturer	AVIVA Systems Biology
Amount	50 ug
Category	Oncology Neuroscience Neural Epigenetics By Cell Type Blastoma Carcinoma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins By Organ Lung Cancer Breast Cancer
Type	Proteins Recombinant
Specific against	Human (Homo sapiens)
Host	E.coli
Purity	>90% (SDS-PAGE)
Dry ice	Yes
Citations	F-box protein Fbxl18 mediates polyubiquitylation and proteasomal degradation of the pro-apoptotic SCF subunit Fbxl7: Y. Liu, et al.; Cell Death Dis. 6, e1630 (2015), Application(s): Assay, Abstract; Full Text Pro-apoptotic F-box protein Fbxl7 regulates mitochondrial function by mediating the ubiquitylation and proteasomal degradation of survivin: Y. Liu, et al.; J. Biol. Chem. 290, 11843 (2015), Application(s): Assay, Abstract; Full Text UBXN2A regulates nicotinic receptor degradation by modulating the E3 ligase activity of CHIP: Y. Teng, et al.; Biochem. Pharmacol. 97, 518 (2015), Application(s): Western Blot, Abstract; Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation: A. L. Haas, et al.; J. Biol. Chem. 257, 2543 (1982), Abstract; Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system: A. L. Cienchanover; PNAS 78, 761 (1981), Abstract;
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	A1S9;A1S9T;A1S9T and BN75 temperature sensitivity complementing;A1ST;AMCX1;CFAP124;GXP1;POC20;POC20 centriolar protein homolog;Protein A1S9;SMAX2;testicular secretory protein Li 63;UBA1,ubiquitin-activating enzyme E1 homolog A;UBA1A;UBE1;UBE1X;Ubiquitin-activating enzyme E1;ubiquitin-like modifier-activating enzyme 1;VEXAS.
Shipping Condition	Dry ice
Available
Manufacturer - Type	Protein
Manufacturer - Category	Root Catalog/Products/Recombinant Proteins
Shipping Temperature	Dry Ice
Molecular Weight	118 kDa
Gene symbol	UBA1
Gene Fullname	ubiquitin like modifier activating enzyme 1
Protein size	Recombinant
Product format	In 50mM TRIS-hydrochloric acid, containing 1.0mM dithiothreitol
Reconstitution and storage	Store at -80C
Description of target	Catalyzes the first step in ubiquitin conjugation to mark cellular proteins for degradation through the ubiquitin-proteasome system (PubMed:1606621, PubMed:1447181). Activates ubiquitin by first adenylating its C-terminal glycine residue with ATP, and thereafter linking this residue to the side chain of a cysteine residue in E1, yielding a ubiquitin-E1 thioester and free AMP (PubMed:1447181). Essential for the formation of radiation-induced foci, timely DNA repair and for response to replication stress. Promotes the recruitment of TP53BP1 and BRCA1 at DNA damage sites (PubMed:22456334).
Protein name	Ubiquitin-like modifier-activating enzyme 1
Purification	Purified by multi-step chromatography.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 50 ug

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Delivery expected until 12/25/2025

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