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Recombinant Human TNFSF4/OX40L Protein (Fc Tag)

Recombinant Human TNFSF4/OX40L Protein (Fc Tag)

Item no.	PKSH030721-1mg
Manufacturer	Elabscience
Amount	1 mg
Quantity options	100 ug 10 ug 1 mg
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Molecular Targets for Neuroscience By Cell Type Carcinoma Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis
Type	Proteins
Format	Lyophilized Powder
Specific against	Human (Homo sapiens)
Host	HEK293 cells
Conjugate/Tag	N-mFc
Purity	> 90 % as determined by reducing SDS-PAGE.
Sequence	Gln51-Leu183
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD134L, CD252, GP34, Glycoprotein Gp34, OX-40, OX40 ligand, OX40L, TAX transcriptionally-activated glycoprotein 1, TNFSF4, TXGP1, Tumor necrosis factor ligand superfamily member 4
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Immune Checkpoint Proteins
Manufacturer - Conjugate / Tag	N-mFc
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	42.1 kDa
Manufacturer - Research Areas	immunology, Stem cells
Background	OX-40L, also known as TNFSF4 and CD252, is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. OX-40L is an important costimulatory molecule that plays a crucial role in the regulation of T-cell-mediated immunity. The interaction of TNFSF4-TNFSF4 is involved in the pathogenesis of multiple autoimmune and inflammatory diseases such as systemic lupus erythematosus (SLE), carotid artery disease and cancer. OX-40L is a ligand for receptor TNFRSF4/OX4. It is found to play a role in T cell antigen-presenting cell (APC) interactions. In surface Ig- and CD40-stimulated B cells, this cytokine along with CD70 has been shown to provide CD28-independent costimulatory signals to T cells. This protein and its receptor are reported to directly mediate adhesion of activated T cells to vascular endothelial cells.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Not validated for activity

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

PKSH030721-1mg-datasheet.pdf

PKSH030721-1mg-safety-datasheet.pdf