TNFSF18, Recombinant, Human (Tumor Necrosis Factor Ligand Superfamily Member 18, Activation-inducible TNF-related Ligand, AITRL, Glucocorticoid-induced TNF-related Ligand, GITRL, hGITRL, TL6, UNQ149/PRO175, MGC138237)

Molecular Biology / MB-Growth Factors-TNF

-20°C

Supplied as a lyophilized powder.

AITRL, a member of the TNF superfamily, is expressed in endothelial cells, and signals through the AITR receptor. AITRL regulates T-cell proliferation and survival, and effectuates the interaction between T lymphocytes and endothelial cells. The AITRL gene codes for a type II transmembrane protein comprised of 177aa, including a 28aa cytoplasmic region, a 21aa transmembrane domain and a 128aa extracellular domain. Recombinant human soluble AITRL is a 14.3kD protein, containing 126aa corresponding to the extracellular domain of AITRL.

Source:
Recombinant protein corresponding to human TNFSF18, expressed in E.coli.

Biological Activity:
Determined by its ability to stimulate IL-8 production by human PBMC using a concentration range of 1-10ng/ml. Note: Results may vary with PBMC donors.

Endotoxin:
<0.1ng/ug (1EU/ug)

AA Sequence:
ETAKEPCMAK FGPLPSKWQM ASSEPPCVNK VSDWKLEILQ NGLYLIYGQV APNANYNDVA PFEVRLYKNK DMIQTLTNKS KIQNVGGTYE LHVGDTIDLI FNSEHQVLKN NTYWGIILLA NPQFI

Storage and Stability:
May be stored at 4°C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.