LY294002 (PI 3 Kinase Inhibitor, 2-(4-Morpholinyl)-8-phenyl-4H-1- benzopyran-4-one)

Blue Ice

307, 4

Supplied as an off-white solid.

A cell-permeable, potent, reversible and specific phosphatidylinositol 3-kinase inhibitor (IC50 = 1.4uM) that acts on the ATP-binding site of the enzyme. Also inhibits nonhomologous DNA end-joining (NHEJ) activity of the 460kD phosphatidylinositol 3-like kinase DNA-PKcs, which is the catalytic subunit of DNA-activated protein kinase. Does not affect the activities of EGF receptor kinase, MAP kinase, PKC, Pl 4-kinase, S6 kinase, and c-Src even at 50uM. Promotes the nuclear accumulation of active GSK-3b. Reported to suppress the proliferation of murine embryonic stem cells. Blocks the proliferation of cultured rabbit aortic smooth muscle cells without inducing apoptosis.

Synonyms:
2-(4-Morpholinyl)-8-phenyl-4H-1-benzopyran-4-one, BRD2 Inhibitor IV, BRD3 Inhibitor III, BRD4 Inhibitor IV

CAS No:
154447-36-6

Molecular Formula:
C₁₉H₁₇NO₃

Primary Target:
Specific phosphatidylinositol 3-kinase inhibitor

Primary Target IC50:
1.4uM

Molecular Weight:
307.4

Solubility:
DMSO (~20mg/ml), EtOH

Storage and Stability:
Store at -20°C. Caution: Light-sensitive. For maximum recovery of product, centrifuge the original vial prior to removing the cap.