Aprotinin, Bovine (US/North America) (Pancreatic trypsin inhibitor)

Molecular Biology / MB-Protease Inhibitors

-20°C

White or yellowish powder

Aprotinin inhibits the activity of several proteolytic enzymes such as chymotrypsin, kallikrein, plasmin and trypsin. It is present in blood and in most tissues, with a high concentration in lung, inhibits pro-inflammatory cytokine release and maintains glycoprotein homeostasis. In platelets, aprotinin reduces glycoprotein loss (e.g., GpIb, GpIIb/IIIa), while in granulocytes it prevents the expression of pro-inflammatory adhesive glycoproteins.
Aprotinin is a natural proteinase inhibitor polypeptide consisting of 58 amino acids arranged in a single polypeptide chain, cross-linked by three disulfide bridges and having a molecular mass of 6512D.

Synonyms:
Antikrein; Antilysin; Antilysine; Aprostat; Aprotinin; BPTI; BPTI Trypsin Inhibitor; Basic Pancreatic Trypsin Inhibitor; Bayer A 128; Bovine Basic Pancreatic Trypsin Inhibitor; Bovine Pancreatic Trypsin Inhibitor; Bovine Trypsin Inhibitor; Fosten; Kallikrein-trypsin Inactivator; Kiker 52G; Kir Richter; Kunitz Pancreatic Trypsin Inhibitor; Kunitz Protease Inhibitor; Kunitz Trypsin Inhibitor; Kunitz-type Inhibitor; Kunitz-type Proteinase Inhibitor; Kunitz-type Trypsin Inhibitor; Onquinin; Pancreatic Basic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor; Pancreatic Trypsin Inhibitor (Kunitz); Protease Inhibitor, Kunitz Type; RP 9921; Repulson; Trasuylol; Trasylol; Trazinin; Triazinin; Trypsin Inhibitor, Trasylol; Trypsin-kallikrein Inhibitor (Kunitz); Zymofren

CAS No:
9087-70-1

Source:
Bovine lung

Appearance:
White or yellowish powder

Activity (dried basis):
≥5400KIU/mg

Histamine:
≤0.2ug/3EU

Absorbance:
≤0.8

Loss on Drying:
≤2%

Protein impurities of higher molecular mass:
Complies

Bacterial Endotoxins:
None Detected

Abnormal Toxicity:
Non-toxic

Storage and Stability:
Lyophilized powder may be stored at -20°C. Stable for 6 months at -20°C. Reconstitute with ddH2O. Aliquot and store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.