Sunitinib, Free Base

Blue Ice

398, 47

Supplied as a yellow powder.

Sunitinib (as the malate salt) is the active ingredient in the drug sold under the trade name Sutent. This drug is a small molecule receptor tyrosine kinase inhibitor that has been approved in at least one country for the treatment of patients having gastrointestinal stromal tumors or renal cell carcinomas.

Synonyms:
N-[2-(Diethylamino)ethyl]-5-[(Z)-(5-fluoro-1, 2-dihydro-2-oxo-3H-indol-3-ylidene)methyl]-2, 4-dimethyl-1H-pyrrole-3-carboxamide; SU-11248; Sutent; PHA-290940AD; PNU-290940AD

CAS No:
557795-19-4

Molecular Formula:
C22H27FN4O2

Molecular Weight:
398.47

Appearance:
Yellow powder

Purity:
≥99% (HPLC, TLC)

Solubility:
Soluble in DMSO at 40mg/ml; soluble in ethanol at 1.4mg/ml with warming; very poorly soluble in water; maximum solubility in plain water is estimated to be about 10-20uM; buffers, serum, or other additives may increase or decrease the aqueous solubility.

Elemental Analysis Calculated:
%C: 66.31
%H: 6.83
%F: 4.77
%N: 14.06

Storage and Stability:
Lyophilized and reconstituted products are stable for 6 months after receipt at -20°C. Reconstitute with DMSO or EtOH. Aliquot to avoid repeated freezing and thawing. Store at -20°C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.