Fz7-21

Item no.	TMO-TP1263-1mg
Manufacturer	TargetMol
CASRN	2247635-23-8
Amount	1 mg
Quantity options	100 mg 10 mg 1 mg 200 mg 25 mg 50 mg 5 mg
Category	Peptides & Proteins Peptides
Type	Peptides
Specific against	other
Purity	99.80%
Citations	Nile AH, et al. A selective peptide inhibitor of Frizzled 7 receptors disrupts intestinal stem cells. Nat Chem Biol. 2018 Sep;14(9):902.
Smiles	C([C@H](NC([C@H](CC1=CC=CC=C1)NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC([C@@H](NC(=O)[C@H]2N(C([C@H](CC(C)C)NC(C)=O)=O)CCC2)CO)=O)CC(O)=O)=O)CC(O)=O)=O)CC(C)C)=O)CCC(O)=O)=O)=O)C(N[C@H](C(N[C@@H](CC3=CN=CN3)C(N[C@H](C(N[C@H](C(N[C@@H](CC4=CC=C(O)C=C4)C(N)=O)=O)CCSC)=O)[C@H](C)C)=O)=O)CS)=O)C=5C=6C(NC5)=CC=CC6
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	(Ac)-LPSDDLEFWCHVMY-NH2
Shipping Condition	Cool pack
Available
Manufacturer - Targets	Wnt/beta-catenin
Shipping Temperature	Cool pack
Storage Conditions	-20
Molecular Weight	1796.03
Description	Fz7-21 ((Ac)-LPSDDLEFWCHVMY-NH2) is a peptide antagonist of FZD7 . It antagonises WNT3A-induced Wnt-β-catenin signalling in HEK293 expressing FZD7. Fz7-21 impairs Wnt/β-catenin signaling in HEK293 cells stimulated with exogenous WNT3A (IC50=100 nM) or transfected with a construct expressing WNT3A or WNT1. Fz7-21 also blocks WNT3A-mediated stabilization of β-catenin in mouse L cells (IC50=50 nM).
Pathways	Cytoskeletal Signaling\|\|\|Stem Cells

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