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Iodophenpropit (dihydrobromide)

Iodophenpropit (dihydrobromide)

Item no.	HY-107568-5mg
Manufacturer	MedChem Express
CASRN	145196-87-8
Amount	5 mg
Quantity options	100 mg 10 mg 1 ea 1 mg 5 mg
Category	Inhibitors & Compound Libraries Small Molecules
Type	Molecules
Specific against	other
Purity	99.70
Citations	[1]Jansen FP, et al. The first radiolabeled histamine H3 receptor antagonist, [<sup>125</sup>I]Iodophenpropit: saturable and reversible binding to rat cortex membranes. Eur J Pharmacol. 1992 Jul 7;217(2-3):203-5.\|[2]Leurs R, et al. Evaluation of the receptor selectivity of the H3 receptor antagonists, Iodophenpropit and thioperamide: an interaction with the 5-HT3 receptor revealed. Br J Pharmacol. 1995 Oct;116(4):2315-21.\|[3]Allen MC. Agonist and antagonist effects of histamine H3 receptor ligands on 5-HT3 receptor-mediated ion currents in NG108-15 cells. Eur J Pharmacol. 1998 Nov 20;361(2-3):261-8.\|[4]Trivendra Tripathi, et al. In vivo immunomodulatory profile of histamine receptors (H1, H2, H3 and H4): a comparative antagonists study. Asian Pac J Trop Med. 2010 Jun;3(6):465-470.
Smiles	N=C(SCCCC1=CNC=N1)NCCC2=CC=C(I)C=C2.[H]Br.[H]Br
ECLASS 10.1	32169090
ECLASS 11.0	32169090
UNSPSC	12000000
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	COVID-19-immunoregulation
Manufacturer - Targets	Histamine Receptor
Shipping Temperature	Blue Ice
Storage Conditions	-20°C (Powder, protect from light, stored under nitrogen)
Molecular Weight	576.13
Product Description	Iodophenpropit dihydrobromide is a potent and selective histamine H3 receptor antagonist. The binding of [125I]Iodophenpropit is selective, saturable, readily reversible, and of high affinity (KD 0.32 nM)[1].
Manufacturer - Research Area	Inflammation/Immunology
Solubility	DMSO: 57.6 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	GPCR/G Protein; Immunology/Inflammation; Neuronal Signaling
Isoform	H3 Receptor
Clinical information	No Development Reported

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HY-107568-5mg-safety-datasheet.pdf