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Cobimetinib (hemifumarate)

Cobimetinib (hemifumarate)

Item no.	HY-13064A-100mg
Manufacturer	MedChem Express
CASRN	1369665-02-0
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 50 mg 5 mg
Category	Oncology Neuroscience Neural Signaling Inhibitors & Compound Libraries Small Molecules By Organ Lung Cancer Skin Cancer
Type	Inhibitors
Specific against	other
Purity	99.73
Citations	[1]Hoeflich KP, et al. Intermittent administration of MEK inhibitor GDC-0973 plus PI3K inhibitor GDC-0941 triggers robust apoptosis and tumor growth inhibition. Cancer Res. 2012 Jan 1;72(1):210-9.\|[2]Choo EF, et al. PK-PD modeling of combination efficacy effect from administration of the MEK inhibitor GDC-0973 and PI3K inhibitor GDC-0941 in A2058 xenografts. Cancer Chemother Pharmacol. 2013 Jan;71(1):133-43.\|[3]Wong H, et al. Bridging the gap between preclinical and clinical studies using pharmacokinetic-pharmacodynamic modeling: an analysis of GDC-0973, a MEK inhibitor. Clin Cancer Res. 2012 Jun 1;18(11):3090-9.\|[4]Corazao-Rozas P, et al. Mitochondrial oxidative phosphorylation controls cancer cell's life and death decisions upon exposure to MAPK inhibitors. Oncotarget. 2016 Feb 29. doi: 10.18632/oncotarget.7790. Cancer Res. 2022 May 18;canres.4152.2021.\|ACS Comb Sci. 2019 Dec 9;21(12):805-816.\|Bioact Mater. 8 September 2021.\|Biomolecules. 2021 Mar 30;11(4):518.\|bioRxiv. 2019 Sep.\|bioRxiv. 2024 May 31:2024.05.30.596676.\|bioRxiv. 2024 September 19.\|Blood Cancer J. 2022 Jan 11;12(1):5.\|Cancer Metab. 2024 Jun 30;12(1):19.\|Cancer Res. 2021 Feb 15;canres.2370.2020.\|Cancers (Basel). 2022 Mar 19;14(6):1575.\|Cancers (Basel). 2023 Jun 22, 15(13), 3289.\|Cancers. 2019 Feb 1;11(2):164.\|Cell Rep. 2023 Jun 27;42(7):112696.\|Cell Rep. 2023 May 29;42(6):112570.\|Cell Syst. 2020 Nov 18;11(5):478-494.e9.\|Cell Syst. 2025 Feb 26:101203.\|Department of Microbiology. Oslo University. 2017 May.\|Elife. 2021 Oct 27;10:e65759.\|EMBO Mol Med. 2021 Nov 15;e14511.\|Exp Cell Res. 2020 Aug 1;393(1):112054.\|Int J Oncol. 2020 Jun;56(6):1429-1441.\|J Control Release. 2015 Oct 21;220(Pt A):160-168. \|J Exp Med. 2022 Apr 4;219(4):e20210739.\|J Invest Dermatol. 2021 Sep 14;S0022-202X(21)01672-9.\|J Invest Dermatol. 2024 Sep 30:S0022-202X(24)02160-2.\|Methods Mol Biol. 2018;1711:351-398.\|Mol Cancer Res. 2018 Mar;16(3):543-553.\|Mol Immunol. 2024 Jul:171:105-114.\|Nat Nanotechnol. 2021 Jul;16(7):830-839.\|Neuro Oncol. 2019 Mar 18;21(4):486-497. \|Oncotarget. 2020 Nov 3;11(44):3921-3932.\|Patent. US20170020964A1.\|Patent. US20170326205A1.\|Patent. US9724393B2.\|Patent. WO2020142349A1.\|PLoS One. 2024 Nov 1;19(11):e0308647.\|Research Square Preprint. 2022 Jul.\|Research Square Preprint. 2024 Nov 06.\|Research Square Preprint. 2024 Oct 10.\|School of Health Sciences. Northeastern University. 2016 Jan.\|Sci Data. 2024 Sep 19.\|Sci Signal. 2018 Oct 30;11(554):eaar6795.\|Sci Transl Med. 2018 Jul 18;10(450):eaaq1093.\|Sci Transl Med. 2021 Jan 27;13(578):eaba7308.\|SSRN. 2020 May.
Smiles	OC1(CN(C(C2=C(NC3=C(F)C=C(I)C=C3)C(F)=C(F)C=C2)=O)C1)[C@H]4NCCCC4.O=C(/C=C/C(O)=O)O
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	GDC-0973 (hemifumarate),XL-518 (hemifumarate)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-Kinase/protease
Manufacturer - Targets	Apoptosis; MEK
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	589.25
Product Description	Cobimetinib hemifumarate is a novel selective MEK1 inhibitor, and the IC50 value against MEK1 is 4.2 nM.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 50 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; MAPK/ERK Pathway
Isoform	MEK1
Clinical information	Launched

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HY-13064A-100mg-safety-datasheet.pdf