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Berubicin

Berubicin

Item no.	HY-14942-5mg
Manufacturer	MedChem Express
CASRN	677017-23-1
Amount	5 mg
Quantity options	1 mg 5 mg
Category	Reagents & Chemicals Standards, Ladders & Markers
Type	Standard
Specific against	other
Purity	87.76
Citations	[1]Kazerooni R, et al. Phase I clinical pharmacokinetics of RTA 744 (berubicin (B)), a blood-brain barrier penetrating anthracycline active against high grade glioma, and evaluation of its 13-hydroxy metabolite, berubicinol (B-ol)[J]. Molecular Cancer Therapeutics, 2007, 6(11_Supplement): B101-B101.
Smiles	OC1=C2C([C@@]([H])(O[C@H]3C[C@H](N)[C@H](OCC4=CC=CC=C4)[C@H](C)O3)C[C@@](C(CO)=O)(O)C2)=C(O)C5=C1C(C6=CC=CC(OC)=C6C5=O)=O
ECLASS 10.1	42021590
ECLASS 11.0	42021590
UNSPSC	12352202
Alias	RTA 744 (free base),WP 744 (free base),WP 769
Shipping Condition	Cool pack
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	Apoptosis; Caspase; NF-κB
Shipping Temperature	Blue Ice
Storage Conditions	-20°C, 3 years (Powder)
Molecular Weight	633.64
Product Description	Berubicin (RTA 744 free base) is a Doxorubicin (HY-15142A) analog that can cross the blood-brain barrier. Berubicin inhibits P-gp and MRP1-mediated efflux and suppresses glioblastoma multiforme (GBM). Berubicin exerts toxic effects on leukemia cells by activating nuclear factor κB (NF-κB) and induces apoptosis in neuroblastoma cells. Berubicin can be used in the study of tumors related to the nervous system[1][2][3][4][5].
Manufacturer - Research Area	Cancer; Neurological Disease
Solubility	DMSO : 100 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; NF-κB
Clinical information	Phase 2
Isoform	Caspase 3; Caspase 9; NF-κB

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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