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CBL0137 (hydrochloride)

CBL0137 (hydrochloride)

Item no.	HY-18935A-100mg
Manufacturer	MedChem Express
CASRN	1197397-89-9
Amount	100 mg
Quantity options	100 mg 10 mM/1 mL 10 mg 25 mg 2 mg 50 mg 5 mg
Category	Oncology Inhibitors & Compound Libraries Small Molecules By Organ Skin Cancer Colorectal Cancer Pancreatic Cancer
Type	Inhibitors
Specific against	other
Purity	99.72
Citations	[1]Burkhart C, et al. Curaxin CBL0137 eradicates drug resistant cancer stem cells and potentiates efficacy of gemcitabine in preclinical models of pancreatic cancer. Oncotarget. 2014 Nov 30;5(22):11038-53.\|[2]Gasparian AV, et al. Curaxins: anticancer compounds that simultaneously suppress NF-κB and activate p53 by targeting FACT. Sci Transl Med. 2011 Aug 10;3(95):95ra74. Adv Mater. 2024 Jul;36(29):e2313991.\|Cancer Res. 2021 Jun 1;81(11):3105-3120.\|Cell Death Dis. 2020 Dec 2;11(12):1029.\|Cell. 2024 Dec 26;187(26):7533-7550.e23.\|Mol Med Rep. 2024 Nov;30(5):209.\|Oncogene. 2022 Nov 10.\|Cell Death Dis. 2024 Oct 27;15(10):779.\|Eur J Med Chem. 2024 Apr 15:270:116377.
Smiles	CC(NCCN1C2=C(C3=C1C=CC(C(C)=O)=C3)C=C(C(C)=O)C=C2)C.[H]Cl
ECLASS 10.1	32160490
ECLASS 11.0	32160490
UNSPSC	12000000
Alias	Curaxin-137 (hydrochloride),CBL-C137 (hydrochloride)
Shipping Condition	Room temperature
Available
Manufacturer - Type	Reference compound
Manufacturer - Applications	Cancer-programmed cell death
Manufacturer - Targets	MDM-2/p53; NF-κB
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture)
Molecular Weight	372.89
Product Description	CBL0137 hydrochloride is an inhibitor of the histone chaperone, FACT. CBL0137 hydrochloride can also activate p53 and inhibits NF-κB with EC50s of 0.37 and 0.47 μM, respectively.
Manufacturer - Research Area	Cancer
Solubility	DMSO: 33.33 mg/mL (ultrasonic)\|H2O: 10 mg/mL (ultrasonic)
Manufacturer - Pathway	Apoptosis; NF-κB
Isoform	NF-κB
Clinical information	Phase 2

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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HY-18935A-100mg-safety-datasheet.pdf