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4-MU-α-GlcNS (sodium)

4-MU-α-GlcNS (sodium)

Item no.	HY-D1632-500ug
Manufacturer	MedChem Express
CASRN	460085-45-4
Amount	500 ug
Quantity options	100 mg 1 ea 500 ug
Category	Reagents & Chemicals Biochemicals
Type	Chemicals
Specific against	other
Purity	99.81
Citations	[1]Karpova EA, et al. A fluorimetric enzyme assay for the diagnosis of Sanfilippo disease type A (MPS IIIA). J Inherit Metab Dis. 1996;19(3):278-85. \|[2]Dasgupta F, et al. Synthesis of 7-O-(2-deoxy-2-sulfamido-alpha-D-glucopyranosyl)-4-methylcoumarin sodium salt: a fluorogenic substrate for sulfamidase. Carbohydr Res. 2002 Jun 5;337(11):1055-8. \|[3]G. Civallero, et al. Assay of heparan-N-sulfamidase in dried leukocytes impregnated in filter paper: A new tool for the identification of Mucopolisaccharidosis IIIA and potentially other lysosomal disorders, Molecular Genetics and Metabolism. 2013;108(4): 267-268.
Smiles	O=S(N[C@H]([C@H]([C@@H]([C@H](O1)CO)O)O)[C@H]1OC2=CC=C(C(C)=CC(O3)=O)C3=C2)(O[Na])=O
ECLASS 10.1	32160000
ECLASS 11.0	32160000
UNSPSC	12000000
Shipping Condition	Room temperature
Available
Manufacturer - Type	Dye Reagents
Manufacturer - Targets	Fluorescent Dye
Shipping Temperature	Room Temperature
Storage Conditions	4°C (Powder, sealed storage, away from moisture and light)
Molecular Weight	439.37
Product Description	4-MU-α-GlcNS sodium is a fluorogenic substrate of heparin sulphamidase, is desulfurized into 4-MU-α-GlcNH2. 4-MU-α-GlcNH2 can liberate 4-methylumbelliferone (4-MU, fluorescent product) via α-glucosaminidase catalysis, with the emission wavelength maxima of 445-454 nm. 4-MU-α-GlcNS sodium can be used to heparin sulphamidase deficiencies associated with Mucopolisaccaridosis IIIA and other lysosomal disorders researches[1][2][3].
Manufacturer - Research Area	Others
Solubility	DMSO: 4.39 mg/mL (ultrasonic; warming)
Manufacturer - Pathway	Others
Clinical information	No Development Reported

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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