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Human Apolipoprotein A-I

Human Apolipoprotein A-I

Manufacturer	ProSpec
Category	Metabolism Glucose Homeostasis Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Specific against	Human
Amount	100ug
Item no.	cyt-037-100ug
eClass 6.1	32161000
eClass 9.0	42030690
Available
Synonyms	Apolipoprotein A-I, Apo-AI, ApoA-I, APOA1, MGC117399
Introduction	APOA1 (Apolipoprotein A-1) is a human protein with a specific role in lipid metabolism being the main protein component of HDL in the plasma. APOA1 promotes cholesterol efflux from tissues to the liver for excretion. Furthermore, APOA1 is a cofactor for LCAT, which is responsible for the formation of most plasma cholesteryl esters. In addition, APOA1 activates spermatozoa motility as part of the SPAP complex. The APOA1 gene is strongly linked with two other apolipoprotein genes on chromosome 11. Defects in the APOA1 gene are linked to HDL deficiency including Tangier disease, and with systemic non-neuropathic amyloidosis. High levels of APOA1 are linked to the manifestation of asthma and atopy.
Description	APOA1 Human isolated from Human HDL is a single, glycosylated, polypeptide chain having a molecular mass of 28.3kDa. APOA1 is purified using delipidation and gel permeation chromatographic technique.
Source	Human HDL.
Physical Appearance	Sterile filtered colorless solution.
Formulation	The APOA1 1mg/ml solution contains 10mM Ammonium Bicarbonate at pH7.4.
Purity	Greater than 95.0% as determined by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage	APOA1 although stable at 4C for 1 week, should be stored below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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cyt-037-100ug-safety-datasheet.pdf