CNTF

Item no.	cyt-272-1mg
Manufacturer	ProSpec
Amount	1 mg
Quantity options	1 mg 20 ug 5 ug
Category	Neuroscience Metabolism Diabetes Regulation of Appetite Molecular Targets for Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Human (Homo sapiens)
Purity	Greater than 98.0% as determined by(a) Analysis by RP-HPLC.<br />(b) Analysis by SDS-PAGE.
Sequence	The sequence of the first five N-terminal amino acids was determined and was found to be Met-Ala-Phe-Thr-Glu.
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	CNTF,HCNTF,CNTF,Ciliary Neurotrophic Factor
Similar products	CNTF
Available
Manufacturer - Category	CYTOKINES AND GROWTH FACTORS
Storage Conditions	Lyophilized Ciliary Neurotrophic Factor although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution CNTF should be stored at 4C between 2-7 days and for future use below -18C. Please prevent freeze-thaw cycles.
Description	Recombinant Human Ciliary Neurotrophic Factor
Formulation	Lyophilized from a concentrated (1mg/ml) solution in water containing 5mM sodium Phosphate buffer pH=7.5 and 5mM sodium chloride.
Introduction	CNTF is a polypeptide hormone whose actions appear to be restricted to the nervous system where it promotes neurotransmitter synthesis and neurite outgrowth in certain neuronal populations. The protein is a potent survival factor for neurons and oligodendrocytes and may be relevant in reducing tissue destruction during inflammatory attacks. A mutation in this gene, which results in aberrant splicing, leads to ciliary neurotrophic factor deficiency, but this phenotype is not causally related to neurologic disease. In addition to the predominant monocistronic transcript originating from this locus, the gene is also co-transcribed with the upstream ZFP91 gene. Co-transcription from the two loci results in a transcript that contains a complete coding region for the zinc finger protein but lacks a complete coding region for ciliary neurotrophic factor. CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Biological Activity	The ED50 as determined by the dose-dependant stimulation of TF-1 cells is 2 ng/ml, corresponding to a Specific Activity of 500, 000IU/mg.
Manufacturer - Format	Sterile Filtered White lyophilized (freeze-dried) powder.

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cyt-272-1mg-safety-datasheet.pdf