PPP3CA

Item no.	enz-051-5ug
Manufacturer	ProSpec
Amount	5 ug
Quantity options	1 ug 50 ug 5 ug
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Enzymes
Type	Enzymes
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 85.0% as determined by SDS-PAGE.
Sequence	MGSSHHHHHH SSGLVPRGSH TGS MSEPKAI DPKLSTTDRV VKAVPFPPSH RLTAKEVFDN DGKPRVDILK AHLMKEGRLE ESVALRIITE GASILRQEKN LLDIDAPVTV CGDIHGQFFD LMKLFEVGGS PANTRYLFLG DYVDRGYFSI ECVLYLWALK ILYPKTLFLL RGNHECRHLT EYFTFKQECK IKYSERVYDA CMDAFDCLPL AALMNQQFLC VHGGLSPEIN T
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Alias	PPP3CA,Serine/threonine-protein phosphatase 2B catalytic subunit alpha isoform,CAM-PRP catalytic subunit,Calmodulin-dependent calcineurin A subunit alpha isoform,PPP3CA,CALNA,CAN,CALN,CCN1,CNA1,PPP2B,CALNA1
Similar products	PPP3CA
Available
Manufacturer - Category	ENZYMES
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human Protein Phosphatase 3, Catalytic subunit, Alpha Isozyme
Formulation	The PPP3CA solution (0.25 mg/ml) contains 20mM Tris-HCl buffer (pH8.0), 0.2M NaCl, 5mM DTT, 1mM EDTA and 20% glycerol.
Introduction	PPP3CA (aka Calcineurin A) is a major soluble calmodulin binding protein in the brain and a Ca2+/calmodulin dependent serine/threonine protein phosphatase, with a relatively limited substrate specificity. PPP3CA activates the T cells of the immune system and can be blocked by drugs. PPP3CA activates NFATc (a transcription factor) by dephosphorylating it. The activated NFATc is subsequently translocated into the nucleus, where it upregulates the expression of interleukin 2.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile Filtered colorless solution.

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