MMP13

Item no.	enz-317-10ug
Manufacturer	ProSpec
Amount	10 ug
Quantity options	100 ug 10 ug 2 ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Enzymes
Type	Enzymes
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 90% as determined by SDS-PAGE.
Sequence	MGSSHHHHHH SSGLVPRGSH MGS YNVFPRT LKWSKMNLTY RIVNYTPDMT HSEVEKAFKK AFKVWSDVTP LNFTRLHDGI ADIMISFGIK EHGDFYPFDG PSGLLAHAFP PGPNYGGDAH FDDDETWTSS SKGYNLFLVA AHEFGHSLGL DHSKDPGALM FPIYTYTGKS HFMLPDDDVQ GIQSLYGPGD EDPNPKHPKT PDKCDPSLSL DAITSLRGET MIFKDRFFWR L
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Alias	MMP13,CLG3,MANDP1,Collagenase 3,Matrix metalloproteinase-13,MMP-13,MMP13
Similar products	MMP 13
Available
Manufacturer - Category	ENZYMES
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human Matrix Metalloproteinase-13
Formulation	The MMP-13 solution (0.5mg/ml) contains 20mM Tris-HCl buffer (pH 8.0), 10% glycerol, 0.15M NaCl and 1mM DTT.
Introduction	Latent recombinant human pro-collagenase (MMP-13) also called collagenase-3 truncated from C-terminal. Matrix Metalloproteinase-13 (MMP-13) is an enzyme that is a member of the MMP extracellular protease family. Extracellular protease enzymes, by virtue of their broad substrate specificities1, play a role in both normal and disease states of tissue proliferation. Among the targets of MMP-13 are collagen, gelatin, entactin, pro-TNF-a, and chemokine SDF-11-4. MMP-13 is found in its latent form as a 52-56 kDa glycosylated proenzyme. Upon cleavage the 22-46 kDa5 MMP-1 becomes active in extracellular matrix remodeling. Because of the prominent role that MMP-1 plays in cell migration and metastasis, it is an important target for inhibition screening.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile Filtered clear solution.

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enz-317-10ug-safety-datasheet.pdf