PIN1

Item no.	enz-331-20ug
Manufacturer	ProSpec
Amount	20 ug
Quantity options	1 mg 20 ug 5 ug
Category	Neuroscience Molecular Targets for Neuroscience Peptides & Proteins Enzymes
Type	Enzymes
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 95.0% as determined by(a) Analysis by RP-HPLC.<br />(b) Analysis by SDS-PAGE.
Sequence	MADEEKLPPG WEKRMSRSSG RVYYFNHITN ASQWERPSGN SSSGGKNGQG EPARVRCSHL LVKHSQSRRP SSWRQEKITR TKEEALELIN GYIQKIKSGE EDFESLASQF SDCSSAKARG DLGAFSRGQM QKPFEDASFA LRTGEMSGPV FTDSGIHIIL RTE.
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Alias	PIN1,Peptidyl-prolyl cis-trans isomerase NIMA-interacting 1,EC 5 2 1 8,Rotamase Pin1,PPIase Pin1,DOD,UBL5,PIN1,PPIase
Similar products	PIN1
Available
Manufacturer - Category	ENZYMES
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human Peptidyl-Prolyl Cis/Trans Isomerase NIMA-Interacting 1
Formulation	The protein containing 20mM Tris-HCl buffer (pH7.5) 0.1M NaCl, 5mM DTT & 20% Glycerol.
Introduction	Human Pin 1 is a peptidyl-prolyl cis/trans isomerase (PPIase) that interacts with NIMA and essential for cell cycle regulation Pin1 is nuclear PPIase containing a WW protein interaction domain, and is structurally and functionally related to Ess1/Ptf1, an essential protein in budding yeast. PPIase activity is necessary for Ess1/Pin1 function in yeast. Pin1 is thus an essential PPIase that regulates mitosis presumably by interacting with NIMA and attenuating its mitosis-promoting activity. Substrates of Pin1 include the mitotic regulators (Cdc25 phosphatase and NIMA, PLK I, Wee, and Myt1 kinases), several transcription factors like b-Catenin, c-Jun, and the tumor suppressor protein p53, and some specific proteins like the RNA Pol II, the cytoskeleton protein tau, and the G1/S protein Cyclin D1.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile filtered colorless solution.

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enz-331-20ug-safety-datasheet.pdf