Recombinant Human Histamine N-Methyltransferase

HNMT is located in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammals brain, N(tau)-methylation controls the neurotransmitter activity of histamine since diamine oxidase is not located in the central nervous system. A well known genetic polymorphism influences the activity levels of HNMT gene product in red blood cells. HNMT inactivates histamine by n-methylation. HNMT is involved in degrading histamine and in regulating the airway response to histamine. Histamine is involved in regulation and modulation of immune response through the stimulation of four distinct subtypes of receptors, H1, H2, H3, and H4, that present on the target cells. Histamine is inactivated by the histamine-metabolizing enzyme HNMT in bronchus, kidney, and the central nervous system.

Escherichia Coli.

The HNMT solution contains 20mM Tris-HCl pH-8 and 10% glycerol.

ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.

HNMT Recombinant Human although stable at 4C for 30 days, should be stored desiccated below -20C for periods greater than 30 days.
Please avoid freeze-thaw cycles.