FKBP4

Item no.	enz-412-50ug
Manufacturer	ProSpec
Amount	50 ug
Quantity options	10 ug 1 mg 50 ug
Category	Neuroscience Neuroinflammation Protein Aggregation, Clearance & Misfolding Peptides & Proteins Enzymes
Type	Enzymes
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 90.0% as determined by SDS-PAGE.
Sequence	MGSSHHHHHH SSGLVPRGSH MTAEEMKATE SGAQSAPLPM EGVDISPKQD EGVLKVIKRE GTGTEMPMIG DRVFVHYTGW LLDGTKFDSS LDRKDKFSFDLGKGEVIKAW DIAIATMKVG EVCHITCKPE YAYGSAGSPP KIPPNATLVF EVELFEFKGE DLTEEEDGGI IRRIQTRGEG YAKPNEGAIV EVALEGYYKDKLFDQRELRF EIGEGENLDL PYGLERAIQR MEKG
ECLASS 10.1	32160410
ECLASS 11.0	32160410
UNSPSC	12352204
Alias	FKBP4,HBI,p52,Hsp56,FKBP52,FKBP59,PPIase,FKBP4,FK506-binding protein 4,Peptidyl-prolyl cis-trans isomerase,HSP-binding immunophilin,FKBP52 protein,52 kDa FK506-binding protein,p59 protein
Similar products	FKBP4
Available
Manufacturer - Category	ENZYMES
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human FK506 Binding Protein 4
Formulation	The FKBP4 protein solution contains 20mM Tris-HCl, pH-8 and 10% glycerol.
Introduction	FKBP4 is part of the immunophilin protein family, which takes part in immunoregulation and necessary cellular processes concerning protein folding and trafficking. FKBP4 is a cis-trans prolyl isomerase that connects to the immunosuppressants FK506 and rapamycin. FKBP4 has high structural and functional similarity to FKBP1A, though, FKBP4 does not have immunosuppressant activity when complexed with FK506. FKBP4 interacts with interferon regulatory factor-4 and is involved in immunoregulatory gene expression in B and T lymphocytes. FKBP4 is known to connect with phytanoyl-CoA alpha-hydroxylase. FKBP4 associates with HSP90 & HSP70 thus takes part in the intracellular trafficking of hetero-oligomeric forms of the steroid hormone receptors. FKBP4 highly associates with adeno-associated virus type 2 vectors (AAV) resulting in a considerable increase in AAV-mediated transgene expression in human cell lines. FKBP4 is involved in the optimal use of AAV vectors in human gene therapy.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile filtered colorless solution.

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enz-412-50ug-safety-datasheet.pdf