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Human Protirelin (Thyrotropin Releasing Hormone)

Human Protirelin (Thyrotropin Releasing Hormone)

Manufacturer	ProSpec
Category	Peptides & Proteins Recombinant Proteins
Type	Hormones
Specific against	Human
Amount	250mg
Item no.	hor-264-250mg
eClass 6.1	32160405
eClass 9.0	32160405
Available
Synonyms	Thyroliberin, TRH, MGC125964, MGC125965, Protirelin, TRF
Introduction	Thyrotropin-releasing hormone (TRH), also called thyrotropin-releasing factor (TRF), thyroliberin or protirelin, is a tripeptide hormonethat stimulates the release of thyroid-stimulating hormoneand prolactinby the anterior pituitary. TRH is produced by the hypothalamus, near the paraventricular nucleus. It travels across the median eminenceto the pituitary via the hypophyseal portal system. It is released from cells called thyrotropes. In addition to the brain, TRH can also be detected in other areas of the body including the gastrointestinal systemand pancreatic islets. Protirelin stimulates the secretion of pituitary thyroid stimulating hormone from the anterior pituitary and has been shown that protirelin increases secretion of prolactin. Protirelin is identified as 5-oxo-L-prolyl-L-histidyl-L-proline amide. It is a synthetic tripeptide that is believed to be structurally identical to the naturally-occurring thyrotropin-releasing hormone produced by the hypothalamus.
Description	Thyrotropin Releasing Hormone Human C₁₆H₂₂N₆O₄ has a molecular mass of 362.4 Dalton. The TRH is purified by proprietary chromatographic techniques.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The TRH was lyophilized with no additives.
Purity	Greater than 99.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Amino acid sequence	Pyr-His-Pro-NH₂.
Storage	Lyophilized Protirelin although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TRH should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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hor-264-250mg-safety-datasheet.pdf