MMACHC

Item no.	pro-1119-20ug
Manufacturer	ProSpec
Amount	20 ug
Quantity options	1 mg 20 ug 5 ug
Category	Food Safety Vitamines Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Liquid
Specific against	Human (Homo sapiens)
Purity	Greater than 90.0% as determined by SDS-PAGE.
Sequence	MGSSHHHHHH SSGLVPRGSH MGSH MEPKVA ELKQKIEDTL CPFGFEVYPF QVAWYNELLP PAFHLPLPGP TLAFLVLSTP AMFDRALKPF LQSCHLRMLT DPVDQCVAYH LGRVRESLPE LQIEIIADYE VHPNRRPKIL AQTAAHVAGA AYYYQRQDVE ADPWGNQRIS GVCIHPRFGG WFAIRGVVLL PGIEVPDLPP RKPHDCVPTR ADRIALLEGF NFHWRDWTYR D
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	MMACHC,Methylmalonic aciduria and homocystinuria type C protein,MMACHC,cblC,RP11-291L19 3
Similar products	MMACHC
Available
Manufacturer - Category	RECOMBINANT & NATURAL PROTEINS
Storage Conditions	Store at 4C if entire vial will be used within 2-4 weeks. Store, frozen at -20C for longer periods of time. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Avoid multiple freeze-thaw cycles.
Description	Recombinant Human Methylmalonic Aciduria cblC type, with Homocystinuria
Formulation	MMACHC protein solution (0.5mg/ml) containing 20mM Tris-HCl buffer (pH 8.0), 0.15M NaCl, 10% glycerol and 1mM DTT.
Introduction	Though the exact role of MMACHC is unknown, its C-terminal region shows similarity to TonB, which is a bacterial protein involved in energy transduction for cobalamin (vitamin B12) uptake. Therefore, it is suggested that MMACHC may have a role in the binding and intracellular trafficking of cobalamin. MMACHC mutations are linked with methylmalonic aciduria and homocystinuria type cblC. MMACHC is widely expressed, it is expressed at higher level in the fetal liver, however it is also expressed in the spleen, lymph node, thymus and bone marrow. MMACHC is weakly or not expressed in the peripheral blood leukocytes.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Manufacturer - Format	Sterile Filtered colorless solution.

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pro-1119-20ug-safety-datasheet.pdf