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Recombinant Human B-Cell Leukemia/Lymphoma 2, (1-206 a.a.)

Recombinant Human B-Cell Leukemia/Lymphoma 2, (1-206 a.a.)

Item no.	pro-630-10ug
Manufacturer	ProSpec
Amount	10ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins
Specific against	Human (Homo sapiens)
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Similar products	Bcl-2
Available
Synonyms	Apoptosis regulator Bcl-2, BCL2, B-cell CLL/lymphoma 2, Bcl-2
Introduction	BCL2 gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
Description	Bcl-2 Human Recombinant produced in E.Coli is a single, non-glycosylated polypeptide chain containing amino acids 1-206. The wild type Bcl-2 is missing 12 amino acids from C-terminus. C-terminus is fused to His-Tag. C-terminus his-tag, mimics the deleted C-terminus membrane domain thus maintaining its biological activity. Bcl-2 is purified by proprietary chromatographic techniques.
Source	Escherichia Coli.
Physical Appearance	Sterile Filtered White lyophilized (freeze-dried) powder.
Formulation	The protein contains 10mM Tris-HCl pH-8, 1mM EDTA and 250mM NaCl.
Purity	Greater than 95.0% as determined by: (a) Analysis by RP-HPLC. (b) Analysis by SDS-PAGE.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Storage	Lyophilized Bcl-2 although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution Bcl-2 should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.

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All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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pro-630-10ug-safety-datasheet.pdf