mTNFA

Item no.	cyt-252-1mg
Manufacturer	ProSpec
Amount	1 mg
Quantity options	1 mg 20 ug 5 ug
Category	Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis Cholesterol & Lipid Metabolism Regulation of Appetite Peptides & Proteins Recombinant Proteins
Type	Cytokines and Growth Factors
Format	Lyophilized
Specific against	Mouse (Murine, Mus musculus)
Purity	Greater than 97.0% as determined by:<BR>(a) Analysis by RP-HPLC.<BR>(c) Analysis by SDS-PAGE.
Sequence	MLRSSSQNSS DKPVAHVVAN HQVEEQLEWL SQRANALLAN GMDLKDNQLV VPADGLYLVY SQVLFKGQGC PDYVLLTHTV SRFAISYQEK VNLLSAVKSP CPKDTPEGAE LKPWYEPIYL GGVFQLEKGD QLSAEVNLPK YLDFAESGQV YFGVIAL
ECLASS 10.1	42030690
ECLASS 11.0	42030690
UNSPSC	12352202
Alias	mTNFA,TNF-alpha,Tumor necrosis factor ligand superfamily member 2,TNF-a,Cachectin,DIF,TNFA,TNFSF2
Similar products	mTNF a
Available
Manufacturer - Category	CYTOKINES AND GROWTH FACTORS
Storage Conditions	Lyophilized Tumor Necrosis Factor-a although stable at room temperature for 3 weeks, should be stored desiccated below -18C. Upon reconstitution TNF-a should be stored at 4C between 2-7 days and for future use below -18C. For long term storage it is recommended to add a carrier protein (0.1% HSA or BSA). Please prevent freeze-thaw cycles.
Description	Recombinant Mouse Tumor Necrosis Factor-alpha
Formulation	Lyophilized from a0.2um filtered concentrated solution in PBS, pH 7.2.
Introduction	Tumor necrosis factor is a cytokine involved in systemic inflammation and is a member of a group of cytokines that all stimulate the acute phase reaction. TNF is mainly secreted by macrophages. TNF causes apoptotic cell death, cellular proliferation, differentiation, inflammation, tumorigenesis and viral replication, TNF is also involved in lipid metabolism, and coagulation. TNF's primary role is in the regulation of immune cells. Dysregulation and, in particular, overproduction of TNF have been implicated in a variety of human diseases- autoimmune diseases, insulin resistance, and cancer.
Usage	ProSpec's products are furnished for LABORATORY RESEARCH USE ONLY. The product may not be used as drugs, agricultural or pesticidal products, food additives or household chemicals.
Biological Activity	The ED50 as determined by the cytolysis of murine L929 cells in the presence of Actinomycin D is 0.1ng/ml, corresponding to a Specific Activity of 10, 000, 000Units/mg.
Manufacturer - Format	Sterile Filtered White lyophilized (freeze-dried) powder.

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cyt-252-1mg-safety-datasheet.pdf