Mouse TNF-α protein

Cytokine

TNF-α

Lyophilized Mouse TNF-α proteinshould be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.13% HSA or BSA). Please prevent freeze-thaw cycles.

Tumor necrosis factor α (TNF-α), also known as cachectin and TNFSF2, is a pleiotropic pro-inflammatory cytokine secreted by various cells including adipocytes, activated monocytes, macrophages, B cells, T cells and fibroblasts. It belongs to the TNF family of ligands and signals through two receptors, TNFR1 and TNFR2. TNF-α is cytotoxic to a wide variety of tumor cells and is an essential factor in mediating the immune response against bacterial infections. TNF-α also plays a role in the induction of septic shock, auto immune diseases, rheumatoid arthritis, inflammation, and diabetes.

Lyophilized from sterile PBS, pH 7.4.

Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.

E. coli

The recombinant Mouse TNF-α protein consists of 157 amino acids and has a predicted molecular mass of 17 kDa.