Mouse IL-4 protein (Animal-Free)

Cytokine

IL-4

Lyophilized Mouse IL-4 protein (Animal-Free)should be stored desiccated below -20°C. Upon reconstitution, the protein should be stored at 4°C between 2-7 days and for future use below -20°C. For long term storage it is recommended to add a carrier protein (0.15% HSA or BSA). Please prevent freeze-thaw cycles.

Interleukin-4 is a pleiotropic cytokine produced primarily by activated T lymphocytes, basophils and mast cells. It is a glycosylated polypeptide that contains three intrachain disulfide bridges and adopts a bundled four α -helix structure.It plays an important role in the treatment and research of tumor and autoimmune diseases, in addition to its role in mediating inflammatory allergic reaction. Mouse IL-4 is synthesized with a 24 aa signal sequence.Multiple immune response-modulating functions are performed by IL-4 on a variety of cell types and it has an important role in the regulator of isotype switching, induction of IgE production in B lymphocytes and differentiation of precursor T helper cells. IL-4 binds to both membrane-bound and secreted soluble IL-4 receptors.

0.22 µm filtered protein solution is in PBS.

Endotoxin: < 0.1 EU per μg of the protein as determined by the LAL method.

HEK293 Cells

IL-4, Interleukin 4, BCGF1, BSF1