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Rat ACE2 / ACEH Protein, His Tag (MALS verified)

Rat ACE2 / ACEH Protein, His Tag (MALS verified)

Item no.	AC2-R5246-1mg
Manufacturer	ACROBiosystems
Amount	500 ug x 2
Quantity options	500 ug x 2 50 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Rat (Rattus norvegicus)
Host	HEK293
Conjugate/Tag	Unconjugated
Purity	90%
Dry ice	Yes
Citations	(1) Turner AJ., et al., 2002, Can. J. Physiol. Pharmacol. 80 (4): 346-53. (2) Katovich MJ., et al., 2005, Exp. Physiol. 90 (3): 299-305. (3) Donoghue M., et al., 2000, Circ. Res. 87:E1-E9. (4) Tipnis S.R., et al., 2000, J. Biol. Chem. 275:33238-33243. (5) Vickers C., et al., 2002, J. Biol. Chem. 277:14838-14843.
NCBI	NP_001012006.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ACE-2,ACEH,ACE2
Shipping Condition	Dry ice
Available
Manufacturer - Category	Protein
Manufacturer - Conjugate / Tag	N-10xHis, Unconjugated
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	85.5 kDa
Manufacturer - Format	Liquid
Description	Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Background	Angiotensin-converting enzyme 2 (ACE2) is also known as ACEH (ACE homolog), is an integral membrane protein with considerable homologous to ACE, which belongs to the peptidase M2 family. ACE2 is an exopeptidase that catalyses the conversion of angiotensin I to the nonapeptide angiotensin, or the conversion of angiotensin II to angiotensin 1-7. ACE2 may be an important regulator of heart function. In case of human coronaviruses SARS and HCoV-NL63 infections, ACE-2 serve as functional receptor for the spike glycoprotein of both coronaviruses. ACE2 is activated by chloride and fluoride, but not bromide and Inhibited by MLN-4760, cFP_Leu, and EDTA, but not by the ACE inhibitors linosipril, captopril and enalaprilat. ACE2 is active from pH 6 to 9, and the optimum pH is 6.5 in the presence of 1 M NaCl.
Molecule	ACE2
Exp Region	Gln 18 - Thr 740
Characteristics	This protein carries a polyhistidine tag at the N-terminus. The protein has a calculated MW of 85.5 kDa. The protein migrates as 100-116 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation.
Endotoxin	1.0 EU per μg
Buffer	50 mM Tris, 150 mM NaCl, Arginine, pH7.5
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 3 months under sterile conditions.
Protectant	glycerol

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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AC2-R5246-1mg-datasheet.pdf

AC2-R5246-1mg-safety-datasheet.pdf