INSL5/INSL7 Hybrid, Human, Recombinant

The Insulin/Relaxin structural family of proteins consists of at least seven members, each containing an Insulin-like hetero-dimeric structure consisting of two polypeptide chains held together by two inter-chain disulfide bonds. INSL7-INSL5 hybrid contains the B-chain of INSL7 (Relaxin-3), linked to the A-chain of INSL5. The INSL7-INSL5 hybrid protein can specifically activate the G protein coupled receptors, GPCR135 and GPCR142, but unlike Relaxin-3, does not induce significant activation of the LGR7 receptor. Recombinant INSL7-INSL5 hybrid is a hetero-dimeric 5.2 kDa protein consisting of a 27 amino acid B-chain disulfide linked to a 21 amino acid A-chain.

0, 98

Diabetes / Weight Regulation , Lipid Metabolism, Neurobiology

Endotoxin level is <, 0.1 ng/ug of protein (<, 1EU/ug).

Verified by N-terminal and Mass Spectrometry analyses (when applicable).