IL-5, Mouse, Recombinant

IL-5 is a hematopoietic growth factor that stimulates the proliferation and activation of eosinophils. Produced by mast cells, T cells, and eosinophils, IL-5 plays an important role in inducing cell-mediated immunity against parasitic infections and certain tumors. Elevated levels of IL-5 lead to Eosinophilia, which may result in the induction of asthma and other allergic diseases. Human and murine IL-5 is cross-species reactive. Recombinant murine IL-5 is a 26.2 kDa disulfide-linked homodimeric protein containing two 113 amino acid chains.

EDF, BCDFII, TRF

E. Coli

MEIPMSTVVK ETLTQLSAHR ALLTSNETMR LPVPTHKNHQ LCIGEIFQGL DILKNQTVRG GTVEMLFQNL SLIKKYIDRQ KEKCGEERRR TRQFLDYLQE FLGVMSTEWA MEG

The ED 50 was determined by the dose-dependent stimulation of the proliferation of human TF-1 cells is <, 2.0 ng/ml, corresponding to a specific activity of >, 5 x 10^5units/mg.

Verified by N-terminal and Mass Spectrometry analyses (when applicable).