Human IL-3 R Beta / CD131 Protein, Fc Tag (MALS verified)

Protein

RT

75.1 kDa

CD131- the common β Subunit, is a member of the type 1 cytokine
receptor family. There are three major classes of heteroreceptor com_x0002_plexes, where the receptor complex utilises a common shared receptor subunit as a signal-transducing chain along with a cytokine specific subunit. These three classes include those which use gp130, those which use γc and those which use the common β subunit, βc(CD131). CD131 is shared by three of the “four-helical bundle” family of cytokines; IL-3, IL-5 and GM-CSF, and forms a receptor complex along with a cytokine specific α chain for each of these cytokines.Moreover, even though each of these cytokines have their own specific α subunit, the co-utilisation of CD131 suggests a common intra-cellular process of both unique and/or overlapping activities on expressing cells.

CD131

This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 75.1 kDa. The protein migrates as 80-100 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition (SDS-PAGE) due to glycosylation.

50 mM Tris, 100 mM Glycine, 25 mM Arginine, 150 mM NaCl, pH7.5

trehalose