Manufacturer |
ACROBiosystems
|
Category |
|
Type |
Proteins |
Specific against |
Human |
Format |
Powder |
Amount |
25ug |
Item no. |
CD2-H82E7-25ug |
Conjugate/Tag |
His Tag & Avi Tag |
eClass 6.1 |
34160400 |
eClass 9.0 |
42020190 |
Available |
|
Bioactivity Legend 1 |
Immobilized Biotinylated Human Nectin-2, His, Avitag (Cat. No. CD2-H82E7) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human PVRIG, Fc Tag (Cat. No. PVG-H5257) with a linear range of 0.6-10 ng/mL (QC tested). |
Bioactivity Legend 2 |
Immobilized Biotinylated Human Nectin-2, His, Avitag (Cat. No. CD2-H82E7) at 1 μg/mL (100 μL/well) on streptavidin (Cat. No. STN-N5116) precoated (0.5 μg/well) plate can bind Human DNAM-1, Fc Tag (Cat. No. DN1-H5257) with a linear range of 0.039-0.625 μg/m |
Buffer |
PBS, pH7.4 |
Characteristics |
This protein carries a polyhistidine tag at the C-terminus, followed by an Avi tag (Avitag™). The protein has a calculated MW of 39.1 kDa. The protein migrates as 45-50 kDa under reducing (R) condition (SDS-PAGE) due to glycosylation. |
Description |
Poliovirus receptor-related 2 (PVRL2) is also known as nectin-2 and CD112 (formerly herpesvirus entry mediator B, HVEB), which is a human plasma membrane glycoprotein. PVRL2 is one of the plasma membrane components of adherens junctions. PVRL2 also serves as an entry for certain mutant strains of herpes simplex virus and pseudorabies virus, and it is involved in cell to cell spreading of these viruses. Variations in PVRL2 gene have been associated with differences in the severity of multiple sclerosis. Also, PVRL2 binds with low affinity to TIGIT. Furthermore, PVRL2 acts as a receptor for herpes simplex virus 1 (HHV-1) mutant Rid1, herpes simplex virus 1 (HHV-2) and pseudorabies virus (PRV). |
Endotoxin Level |
Less than 1.0 EU per μg by the LAL method. |
Exp Region |
Gln 32 - Leu 360 |
Expression System |
HEK293 |
Molecular Weight |
39.1 kDa |
Molecule |
Nectin-2 |
SDS-PAGE Legend |
Biotinylated Human Nectin-2, His, Avitag on SDS-PAGE under reducing (R) condition. The gel was stained overnight with Coomassie Blue. The purity of the protein is greater than 95%. |
Storage |
-20℃ |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.