Comparison

Human CD28H / IGPR-1 Protein, Fc Tag (MALS verified) European Partner

Item no. CDH-H5251-100ug
Manufacturer ACROBiosystems
Amount 100 ug
Quantity options 100 ug 1 mg
Category
Type Proteins Recombinant
Format Solid
Specific against Human (Homo sapiens)
Host HEK293
Conjugate/Tag Unconjugated, Fc
Purity 95%
Citations (1)Evans E.J., et al., 2005, Nat. Immunol. 6:271-279. (2) Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46. (3) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386.
NCBI AAH15655.1
ECLASS 10.1 32160409
ECLASS 11.0 32160409
UNSPSC 12352202
Alias TMIGD2,IGPR1
Shipping condition Room temperature
Available
Manufacturer - Category
Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag
C-Fc, Unconjugated
Shipping Temperature
RT
Storage Conditions
-20°C
Molecular Weight
40.6 kDa
Description
Human CD28H, Fc Tag (CDH-H5251) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 150 (Accession # AAH15655.1).
Background
CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1, is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue, the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade.
Molecule
CD28H
Exp Region
Leu 23 - Gly 150
Characteristics
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. As a result of glycosylation, the protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition, and 90-130 kDa, 150kDa under non-reducing (NR) condition (SDS-PAGE).
Endotoxin
1.0 EU per μg
Buffer
PBS, pH7.4
Stability
-20°C to -70°C for 12 months in lyophilized state;
-70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower.
Protectant
trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Amount: 100 ug
Available: In stock
available

Delivery expected until 6/12/2025 

Compare

Add to wishlist

Get an offer

Request delivery time

Ask a technical question

Submit a bulk request

Questions about this Product?