Item no. |
CDH-H5251-100ug |
Manufacturer |
ACROBiosystems
|
Amount |
100 ug |
Quantity options |
100 ug
1 mg
|
Category |
|
Type |
Proteins Recombinant |
Format |
Solid |
Specific against |
Human (Homo sapiens) |
Host |
HEK293 |
Conjugate/Tag |
Unconjugated, Fc |
Purity |
95% |
Citations |
(1)Evans E.J., et al., 2005, Nat. Immunol. 6:271-279. (2) Mayya V., et al., 2009, Sci. Signal. 2:RA46-RA46. (3) Wollscheid B., et al., 2009, Nat. Biotechnol. 27:378-386. |
NCBI |
AAH15655.1 |
ECLASS 10.1 |
32160409 |
ECLASS 11.0 |
32160409 |
UNSPSC |
12352202 |
Alias |
TMIGD2,IGPR1 |
Shipping condition |
Room temperature |
Available |
|
Manufacturer - Category |
Protein / Bio-Markers & CD Antigens |
Manufacturer - Conjugate / Tag |
C-Fc, Unconjugated |
Shipping Temperature |
RT |
Storage Conditions |
-20°C |
Molecular Weight |
40.6 kDa |
Description |
Human CD28H, Fc Tag (CDH-H5251) is expressed from human 293 cells (HEK293). It contains AA Leu 23 - Gly 150 (Accession # AAH15655.1). |
Background |
CD28 homolog (CD28H), also called transmembrane and immunoglobulin domain containing 2 (TMIGD2) and IGPR-1, is encoded by the TMIGD2 gene. CD28H is constitutively expressed on naive T and NK cells. After interaction of CD28 homolog with B7 homologue, the peripheral effector and memory T cells can be activated and proliferated by Akt-dependent signalling cascade. Plays a role in cell-cell interaction, cell migration, and angiogenesis. Through interaction with HHLA2, costimulates T-cells in the context of TCR-mediated activation. Enhances T-cell proliferation and cytokine production via an AKT-dependent signaling cascade. |
Molecule |
CD28H |
Exp Region |
Leu 23 - Gly 150 |
Characteristics |
This protein carries a human IgG1 Fc tag at the C-terminus. The protein has a calculated MW of 40.6 kDa. As a result of glycosylation, the protein migrates as 45-60 kDa when calibrated against Star Ribbon Pre-stained Protein Marker under reducing (R) condition, and 90-130 kDa, 150kDa under non-reducing (NR) condition (SDS-PAGE). |
Endotoxin |
1.0 EU per μg |
Buffer |
PBS, pH7.4 |
Stability |
-20°C to -70°C for 12 months in lyophilized state; -70°C for 3 months under sterile conditions after reconstitution._x000D_For long term storage, the product should be stored at lyophilized state at -20°C or lower. |
Protectant |
trehalose |
Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.
All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.