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Human Claudin-18.2 Full Length Protein (VLP)

Human Claudin-18.2 Full Length Protein (VLP)

Item no.	CL2-H52P7-20ug
Manufacturer	ACROBiosystems
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens)
Host	HEK293
Conjugate/Tag	Unconjugated
Dry ice	Yes
NCBI	NP_001002026.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Claudin-18.2,CLDN18,Claudin-18
Shipping Condition	Dry ice
Available
Manufacturer - Category	Protein
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	27.7 kDa \| 56.1 kDa
Manufacturer - Format	Liquid
Description	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Background	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Molecule	Claudin-18.2
Exp Region	Met 1 - Val 261
Characteristics	This protein .
Endotoxin	1.0 EU per μg
Buffer	PBS, pH7.4
Stability	● The product MUST be stored at -70°C or lower upon receipt ● -70°C for 12 months under sterile conditions.
Protectant	trehalose

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

CL2-H52P7-20ug-datasheet.pdf

CL2-H52P7-20ug-safety-datasheet.pdf