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Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)

Human / Cynomolgus Claudin-18.2 Protein, His,Twin-Strep Tag (Detergent)

Item no.	CL2-H5587-20ug
Manufacturer	ACROBiosystems
Amount	20 ug
Quantity options	100 ug 20 ug 500 ug
Category	Peptides & Proteins Recombinant Proteins
Type	Proteins Recombinant
Format	Liquid
Specific against	Human (Homo sapiens), Monkey (Cynomolgus, Simian)
Host	Insect Cells
Conjugate/Tag	Unconjugated, Twin-Strep, HIS
Purity	80%
Dry ice	Yes
NCBI	NP_001002026.1
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Claudin-18.2,CLDN18,Claudin-18
Shipping condition	Dry ice
Available
Specificity	Human / Cynomolgus
Manufacturer - Category	Protein / Bio-Markers & CD Antigens
Manufacturer - Conjugate / Tag	N-10×His & C-Twin-Strep, Unconjugated
Manufacturer - Species	Human / Cynomolgus
Shipping Temperature	Dry ice
Storage Conditions	-70°C
Molecular Weight	26.3 kDa
Description	Human / Cynomolgus Claudin-18.2, His, Twin-Strep Tag (CL2-H5587) is expressed from Baculovirus-Insect cells. It contains AA Met 1 - Ala 200 (Accession # P56856-2). In the region AA Met 1 - Ala 200, the AA sequence of Human and Cynomolgus Claudin-18.2 are homologus.
Background	Claudins (CLDNs) are a family of proteins that form tight junctions and maintain the polarity of epithelial and endothelial cells. CLDN18 is specifically expressed in the stomach and lung. Of the two CLDN18 isoform transcripts produced by alternative splicing, CLDN18.2 is a highly selective gastric lineage marker that determines the gastric phenotype in a neoplastic condition, whereas CLDN18.1 is lung specific. CLDN18.2 is a highly selective gastric lineage antigen expressed exclusively on short-lived differentiated gastric epithelial cells where it has only limited accessibility to antibody drugs.14, 15 CLDN18.2 is maintained during the course of malignant transformation and thus frequently displayed on the surface of human gastric cancer cells.
Molecule	Claudin-18.2
Exp Region	Met 1 - Ala 200
Characteristics	This protein carries a polyhistidine tag at the N-terminus and a twin strep tag at the C-terminus. The protein has a calculated MW of 26.3 kDa.
Endotoxin	1.0 EU per μg
Buffer	50 mM HEPES, 150 mM NaCl, DDM, CHS, pH7.5
Stability	The product MUST be stored at -70°C or lower upon receipt; -70°C for 6 months under sterile conditions.
Protectant	glycerol

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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CL2-H5587-20ug-datasheet.pdf

CL2-H5587-20ug-safety-datasheet.pdf