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Recombinant Human SPHK1/Sphingosine Kinase 1 Protein (His&GST Tag)

Recombinant Human SPHK1/Sphingosine Kinase 1 Protein (His&GST Tag)

Item no.	ELS-PKSH030316-20ug
Manufacturer	Elabscience
Amount	20 ug
Quantity options	20 ug 50 ug
Category	Metabolism Cholesterol & Lipid Metabolism Peptides & Proteins Recombinant Proteins Enzymes Fatty Acid Catabolism
Type	Proteins
Format	Liquid
Specific against	Human (Homo sapiens)
Host	Insect Cells, Baculovirus-Infected Insect Cells
Conjugate/Tag	HIS, GST
Purity	> 95 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Leu 384
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	SPHK, SPHK1, SPK
Similar products	SPHK1, SPK, SPHK
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	N-His-GST
Shipping Temperature	This product is provided as liquid. It is shipped at frozen temperature with blue ice/gel packs. Upon receipt, store it immediately at < - 20°C.
Storage Conditions	Store at < -20°C, stable for 6 months. Please minimize freeze-thaw cycles.
Calculated Molecular Weight	70.3 kDa
Observed Molecular Weight	64 kDa
Research Areas	Signal Transduction, Cancer, Metabolism
Background	SPHK1; also known as sphingosine Kinase 1; catalyzes the phosphorylation of sphingosine to form sphingosine-1-phosphate (S1P). S1P exhibits a broad spectrum of biological activities including cell proliferation; survival; migration; cytoskeletal organization; and morphogenesis. It is a ligand for cell surface G protein-coupled receptors. SPHK 1 is a potential therapeutic target for the control of cancer and inflammation. SPHK1 plays a key role in TNF-alpha signaling and the NF-kappa-B activation pathway important in inflammatory; antiapoptotic; and immune processes.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Not Applicable
Formulation	Supplied as sterile solution of 20mM Tris, 500mM NaCl, 3mM DTT, 10% glycerol, pH 8.0
Activity	Not validated for activity

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSH030316-20ug-datasheet.pdf

ELS-PKSH030316-20ug-safety-datasheet.pdf