Recombinant Human Beta-2-Microglobulin/B2M Protein (HEK293 Cells, His Tag)

C-His

Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.

13.5 kDa

B2M, also known as β 2-Microglobulin or CDABP0092, is a component of MHC class I molecules found expression in all nucleated cells (excludes red blood cells). The major function of MHC class I moleculesis is to display fragments of proteins from within the cell to T-cells and cells containing foreign proteins will be attacked. B2M(β 2-Microglobulin) is a low molecular weight protein. It was demonstrated that B2M(β 2-Microglobulin) was localized in the membranes of nucleated cells and was found to be associated with HL-A antigens.B2M(β 2- Microglobulin) is present in free form in various body fluids and as a subunit of histocompatibility antigens on cell surfaces lateral to theα 3 chain. Unlikeα 3, β 2 has no transmembrane region. Directly above β 2 lies the α 1 chain, which itself is lateral to the α 2. In the absence of B2M(β 2 microglobulin), very limited amounts of MHC class I (classical and non-classical) molecules can be detected on the surface. In the absence of MHC class I, CD8 T cells, a subset of T cells involved in the development of acquired immunity cannot develop. Low levels of B2M(β 2 microglobulin) can indicate non-progression of HIV.

Please refer to the printed manual for detailed information.

Not validated for activity