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Recombinant Mouse CD59a/MAC-IP Protein (Fc Tag)

Recombinant Mouse CD59a/MAC-IP Protein (Fc Tag)

Item no.	ELS-PKSM040522-20ug
Manufacturer	Elabscience
Amount	20 ug
Quantity options	20 ug 50 ug
Category	Neuroscience Neuroinflammation Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Lyophilized Powder
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293 cells
Conjugate/Tag	C-hFc
Purity	> 92 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Lys 95
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AA987121, Cd59, RP24-297H17.1, protectin
Similar products	Cd59, protectin, AA987121, RP24-297H17.1
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-hFc
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	35.4 kDa
Observed Molecular Weight	42 kDa
Background	Protectin, a complement regulatory protein, also known as CD59, or MIRL (membrane inhibitor of reactive lysis) is a small protein that inhibits the complement membrane attack complex by binding C5b678 and preventing C9 from binding and polymerizing. The amino-terminal 25 amino acids represented a typical signal peptide sequence and the carboxy-terminal hydrophobic amino acids were characteristic for phosphatidylinositol-anchored proteins.It was found that the CD59/Protectin antigen is a small protein sometimes associated with larger components (45 and 80 kD) in urine. CD59/Protectin antigen was released from the surface of transfected COS cells by phosphatidylinositol-specific phospholipase C, demonstrating that it is attached to the cell membrane by means of a glycolipid anchor; it is therefore likely to be absent from the surface of affected erythrocytes in the disease paroxysmal nocturnal hemoglobinuria.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Not validated for activity
Protein Construction	A DNA sequence encoding the mouse CD59a (O55186) (Met 1-Lys 95), without the pro peptide, was fused with the Fc region of human IgG1 at the C-terminus.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSM040522-20ug-datasheet.pdf

ELS-PKSM040522-20ug-safety-datasheet.pdf