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Recombinant Mouse c-MET/HGFR Protein (Fc Tag)(Fc Tag)

Recombinant Mouse c-MET/HGFR Protein (Fc Tag)(Fc Tag)

Item no.	ELS-PKSM040581-200ug
Manufacturer	Elabscience
Amount	200 ug
Quantity options	100 ug 200 ug 1 mg
Category	Oncology By Cell Type Blastoma Carcinoma Glioma Hematology Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Adenocarcinoma Mesothelioma
Type	Proteins
Format	Lyophilized Powder
Applications	ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293 cells
Conjugate/Tag	C-hFc
Purity	> 92 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Asn 929
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	AI838057, HGF, HGFR, Par4, c-Met
Similar products	HGFR, c-Met, HGF, Par4, AI838057
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-hFc
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	32&96 kDa
Observed Molecular Weight	43&115-120 kDa
Background	Hepatocyte growth factor receptor (HGFR), also known as c-Met or mesenchymal-epithelial transition factor (MET), is a receptor tyrosine kinase (RTK) that has been shown to be overexpressed and/or mutated in a variety of malignancies. HGFR protein is produced as a single-chain precursor, and HGF is the only known ligand. Normal HGF/HGFR signaling is essential for embryonic development, tissue repair or wound healing, whereas aberrantly active HGFR has been strongly implicated in tumorigenesis, particularly in the development of invasive and metastatic phenotypes. HGFR protein is a multifaceted regulator of growth, motility, and invasion, and is normally expressed by cells of epithelial origin. Preclinical studies suggest that targeting aberrant HGFR signaling could be an attractive therapy in cancer.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Immobilized human HGF at 2 μg/ml (100 μl/well) can bind mouse HGFR with a linear ranger of 1. 28-32ng/ml.
Protein Construction	A DNA sequence encoding the mouse MET (NP_032617.2) extracellular domain (Met 1-Asn 929) was fused with the Fc region of human IgG1 at the C-terminus.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSM040581-200ug-datasheet.pdf

ELS-PKSM040581-200ug-safety-datasheet.pdf