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Recombinant Mouse DDR2 Kinase/CD167b Protein (His Tag)

Recombinant Mouse DDR2 Kinase/CD167b Protein (His Tag)

Item no.	ELS-PKSM040624-100ug
Manufacturer	Elabscience
Amount	100 ug
Quantity options	100 ug 50 ug
Category	Oncology Neuroscience Neural Lineage Markers Neural Signaling Protein Aggregation, Clearance & Misfolding Neural Adhesion Molecules By Cell Type Blastoma Carcinoma Glioma Hematology Leukemia Lymphoma Myeloma Melanoma Sarcoma Peptides & Proteins Recombinant Proteins Astrocytoma By Organ Colorectal Cancer Heart & Blood Cancer Calcium Binding Protein Markers Interneuron Markers
Type	Proteins
Format	Lyophilized Powder
Applications	ELISA
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293 cells
Conjugate/Tag	HIS
Purity	> 95 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Arg 399
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	CD167 antigen-like family member B, CD167b, Ddr2, Discoidin domain receptor 2, Discoidin domain-containing receptor 2, Neurotrophic tyrosine kinase, Ntrkr3, Receptor protein-tyrosine kinase TKT, Tyrosine-protein kinase TYRO10, receptor-related 3, tyro10
Similar products	Discoidin domain-containing receptor 2, CD167 antigen-like family member B, Neurotrophic tyrosine kinase, receptor-related 3, Receptor protein-tyrosine kinase TKT, Ddr2, Ntrkr3, Tyrosine-protein kinase TYRO10, CD167b, Discoidin domain receptor 2, tyro10
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-His
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80℃. Reconstituted protein solution can be stored at 4-8℃ for 2-7 days. Aliquots of reconstituted samples are stable at < -20℃ for 3 months.
Calculated Molecular Weight	44.0 kDa
Observed Molecular Weight	80-90 kDa
Background	Discoidin domain receptor 2 (DDR2) or CD167b (cluster of differentiation 167b) is a kind of protein tyrosine kinases associated with cell proliferation and tumor metastasis, and collagen, identified as a ligand for DDR2, up-regulates matrix metallloproteinase 1 (MMP-1) and MMP-2 expression in cellular matrix. DDR2/CD167b was found to recognise the triple-helical region of collagen X as well as the NC1 domain. Binding to the collagenous region was dependent on the triple-helical conformation. DDR2/CD167b autophosphorylation was induced by the collagen X triple-helical region but not the NC1 domain, indicating that the triple-helical region of collagen X contains a specific DDR2 binding site that is capable of receptor activation. DDR2/CD167b is induced during stellate cell activation and implicate the phosphorylated receptor as a mediator of MMP-2 release and growth stimulation in response to type I collagen. Moreover, type I collagen-dependent upregulation of DDR2/CD167b expression establishes a positive feedback loop in activated stellate cells, leading to further proliferation and enhanced invasive activity.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Measured by its ability to bind rat tail Collagen I in a functional ELISA.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSM040624-100ug-datasheet.pdf

ELS-PKSM040624-100ug-safety-datasheet.pdf