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Recombinant Mouse ALK-1/ACVRL1 Protein (His & Fc Tag)

Recombinant Mouse ALK-1/ACVRL1 Protein (His & Fc Tag)

Item no.	ELS-PKSM040803-100ug
Manufacturer	Elabscience
Amount	100 ug
Quantity options	100 ug 200 ug
Category	Neuroscience Molecular Targets for Neuroscience Neural Signaling Peptides & Proteins Recombinant Proteins
Type	Proteins
Format	Lyophilized Powder
Applications	Cell Culture
Specific against	Mouse (Murine, Mus musculus)
Host	HEK293 cells
Conjugate/Tag	HIS, Fc
Purity	> 95 % as determined by reducing SDS-PAGE.
Sequence	Met 1-Pro 119
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	ACVRL1, ALK-1, Activin receptor-like kinase 1, SKR3, Serine/threonine-protein kinase receptor R3, TGF-B superfamily receptor type I, TSR-I, activin A receptor, activin A receptor type II-like 1
Similar products	ACVRL1, TGF-B superfamily receptor type I, Serine/threonine-protein kinase receptor R3, Activin receptor-like kinase 1, activin A receptor, ALK-1, SKR3, TSR-I, activin A receptor type II-like 1
Shipping Condition	Cool pack
Available
Manufacturer - Category	Recombinant Proteins / Others
Manufacturer - Conjugate / Tag	C-His-Fc
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Generally, lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8°C for 2-7 days. Aliquots of reconstituted samples are stable at < -20°C for 3 months.
Calculated Molecular Weight	39.0 kDa
Observed Molecular Weight	50-55 kDa
Background	Activin A receptor, type II-like 1 (ACVRL1), also known as ALK-1 (activin receptor-like kinase 1), is an endothelial-specific type I receptor of the TGF-beta (transforming growth factor beta) receptor family of ligands. On ligand binding, a heteromeric receptor complex forms consisting of two type II and two type I transmembrane serine/threonine kinases. ACVRL1 protein is expressed in certain blood vessels of kidney, spleen, heart and intestine, serving as an important role during vascular development. Mutations in ACVRL1 gene are associated with hemorrhagic telangiectasia type 2, also known as Rendu-Osler-Weber syndrome 2 and vascular disease.
Endotoxin	< 1.0 EU per μg of the protein as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from sterile PBS, pH 7.4 Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization. Please refer to the specific buffer information in the printed manual.
Activity	Measured by its ability to inhibit BMP9-induced alkaline phosphatase production by MC3T3E1 mouse chondrogenic cells. David, L. et al. (2007) Blood 109:1953. The ED50 for this effect is typically 60-300 ng/mL in the presence of 2 ng/mL of recombiant human BMP9.
Protein Construction	A DNA sequence encoding the mouse ALK1 (NP_033742.2) precursor (Met 1-Pro 119) was fused with the C-terminal polyhistidine-tagged Fc region of human IgG1 at the C-terminus.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

Request Data Sheet

ELS-PKSM040803-100ug-datasheet.pdf

ELS-PKSM040803-100ug-safety-datasheet.pdf