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Recombinant Mouse RANKL/TNFSF11 Protein (Active)

Recombinant Mouse RANKL/TNFSF11 Protein (Active)

Item no.	ELS-PKSM041166-10ug
Manufacturer	Elabscience
Amount	10 ug
Quantity options	10 ug 50 ug
Category	Oncology Neuroscience Neuroinflammation Metabolism Diabetes Glucose Homeostasis By Cell Type Peptides & Proteins Recombinant Proteins Cell Biology Obesity Cell Culture Cytokines Cell Status Necrosis Apoptosis By Organ Lymphatic System Cancer
Type	Proteins
Format	Lyophilized Powder
Specific against	Mouse (Murine, Mus musculus)
Host	E.coli
Purity	> 95 % as determined by SDS-PAGE
Sequence	Gln137-Asp316
ECLASS 10.1	32160409
ECLASS 11.0	32160409
UNSPSC	12352202
Alias	Tumor necrosis factor ligand superfamily member 11,Tnfsf11,Osteoclast differentiation factor,ODF,Osteoprotegerin ligand,OPGL,Receptor activator of nuclear factor kappa-B ligand,RANKL,TNF-related activation-induced cytokine,TRANCE,CD254
Similar products	CD254, RANKL, Tnfsf11, ODF, OPGL, TRANCE, TNF-related activation-induced cytokine, Tumor necrosis factor ligand superfamily member 11, Osteoclast differentiation factor, Osteoprotegerin ligand, Receptor activator of nuclear factor kappa-B ligand
Shipping Condition	Cool pack
Available
Shipping Temperature	This product is provided as lyophilized powder which is shipped with ice packs.
Storage Conditions	Lyophilized proteins are stable for up to 12 months when stored at -20 to -80°C. Reconstituted protein solution can be stored at 4-8C for 2-7 days. Aliquots of reconstituted samples are stable at < -20C for 3 months.
Calculated Molecular Weight	18 kDa
Observed Molecular Weight	20.1 kDa
Background	Mouse tumor necrosis factor ligand superfamily member 11(Tnfsf11) is a member of the tumor necrosis factor (TNF) cytokine family. Tnfsf11 is widely expressed in cells including T cells and T cell rich organs, such as thymus and lymph nodes. This cytokine can bind to TNFRSF11B/OPG andTNFRSF11A/RANK. Tnfsf11 is involved in a number of fundamental biological processes such as acting as regulator of interactions between T-cells and dendritic cells, the regulation of the T-cell-dependent immune response and enhancing bone-resorption in humoral hypercalcemia of malignancy. It augments the ability of dendritic cells to stimulate naive T-cell proliferation.
Endotoxin	< 1.0 EU per ug as determined by the LAL method.
Reconstitution	Please refer to the printed manual for detailed information.
Formulation	Lyophilized from a 0.2 um filtered solution of 20mMTris, 150mMNaCl, 1mMEDTA, pH8.0.
Activity	Measured by its ability to induce osteoclast differentiation of RAW 264.7 mouse monocyte/macrophage cells. The ED50 for this effect is 0.2-1 ng/ml.
Protein Construction	Recombinant Mouse TNF ligand superfamily member 11 is produced by our E.coli expression system and the target gene encoding Gln137-Asp316 is expressed.

Note: The presented information and documents (Manual, Product Datasheet, Safety Datasheet and Certificate of Analysis) correspond to our latest update and should serve for orientational purpose only. We do not guarantee the topicality. We would kindly ask you to make a request for specific requirements, if necessary.

All products are intended for research use only (RUO). Not for human, veterinary or therapeutic use.

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Amount: 10 ug

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Delivery expected until 2/12/2026

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