Recombinant Mouse TNF-alpha/TNFA Protein (aa 80-235)

Recombinant Proteins / Cytokines

This product is provided as lyophilized powder which is shipped with ice packs.

18.2 kDa

Tumor necrosis factor alpha (TNF-alpha), also known as TNF, TNFA or TNFSF2, is the prototypic cytokine of the TNF superfamily, and is a multifunctional molecule involved in the regulation of a wide spectrum of biological processes including cell proliferation, differentiation, apoptosis, lipid metabolism, and coagulation. Two receptors, TNF-R1 (TNF receptor type 1; CD120a; p55/60) and TNF-R2 (TNF receptor type 2; CD120b; p75/80), bind to TNF-alpha. TNF-alpha protein is produced mainly by macrophages, and large amounts of this cytokine are released in response to lipopolysaccharide, other bacterial products, and Interleukin-1 (IL-1). TNF-alpha is involved in fighting against the tumorigenesis, thus, is regarded as a molecular insight in cancer treatment. TNF-alpha Protein & Antibody

< 0.1 EU per μg of the protein as determined by the LAL method.

Lyophilized from sterile PBS, pH 8.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

A DNA sequence encoding the soluble form of mouse TNF-alpha (NP_038721.1) (Leu 80-Leu 235) was expressed, with an initial Met at the C-terminus.