Recombinant Mouse APRIL/TNFSF13 Protein (Fc Tag)

Recombinant Proteins / Others

This product is provided as lyophilized powder which is shipped with ice packs.

42.7 kDa

Tumor necrosis factor ligand superfamily member 13 belongs to the tumor necrosis factor family. It is also known as APRIL, TALL2, TRDL1, and CD256. It is synthesized as a 32 kDa proprotein which is cleaved by furin in the Golgi to release the active 17 kDa soluble molecule. TNFSF13 is a Cytokine that binds to TNFRSF13B/TACI and to TNFRSF17/BCMA and plays a role in the regulation of tumor cell growth. It expressed at high levels in transformed cell lines, cancers of colon, thyroid, lymphoid tissues and specifically expressed in monocytes and macrophages. Its expression by CD4+ T cells inhibits the production of Th2 cytokines and allergic inflammation.

< 1.0 EU per μg of the protein as determined by the LAL method.

Lyophilized from a 0.2 μm filtered solution of 20mM PB, 8% Sucrose, 0.05% Tween 80, pH 6.0.
Normally 5% - 8% trehalose, mannitol and 0.01% Tween 80 are added as protectants before lyophilization.
Please refer to the specific buffer information in the printed manual.

Recombinant Mouse TNFSF13 is produced by our Mammalian expression system and the target gene encoding Ala96-Leu240 is expressed with a Fc tag at the Nterminus.